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Direct myocardial depressant effect of methylmethacrylate monomer

Authors
 Ki Jun Kim  ;  Da Guang Chen  ;  Wyun Kon Park  ;  Carl Lynch III  ;  Namsik Chung 
Citation
 ANESTHESIOLOGY, Vol.98(5) : 1186-1194, 2003 
Journal Title
 ANESTHESIOLOGY 
ISSN
 0003-3022 
Issue Date
2003
MeSH
Anesthesia, Inhalation ; Animals ; Calcium/physiology ; Female ; Guinea Pigs ; Halothane ; Heart/drug effects* ; Heart/physiology ; In Vitro Techniques ; Methylmethacrylate/pharmacology* ; Myocardial Contraction/drug effects* ; Rats ; Rats, Sprague-Dawley ; Vasodilator Agents/pharmacology
Keywords
12717141
Abstract
BACKGROUND: The present study explored the mechanism of direct myocardial depression by methylmethacrylate monomer (MMA). METHODS: Isometric contraction of isolated guinea pig right ventricular papillary muscle was measured in modified normal and 26 mm K+ Tyrode solutions at various stimulation rates. Normal and slow action potentials were evaluated by conventional microelectrode technique. MMA effects on various aspects of sarcoplasmic reticulum function were evaluated by its effect on rapid-cooling contractures, rested-state contraction in rat papillary muscle in modified normal Tyrode solution, and in guinea pig papillary muscle under low Na+ (25 mm) Tyrode solution. Whole cell patch clamp techniques were applied to measure the inward Ca2+ currents (I(Ca)). RESULTS: MMA (0.5, 1.5, and 4.7 mm) caused concentration-dependent depression of peak force and maximal rate of force development to approximately 70, 50, and 20% of baseline from rested state to 3 Hz stimulation rates, respectively. Depression of peak force and maximal rate of force development by MMA was dependent on stimulation frequency, with less depression at higher stimulation rates. In low Na+ Tyrode solution, 1.5 mm MMA depressed peak force of rat and guinea pig myocardium by 20-30%. In 26 mm K+ Tyrode solution, 0.5 and 1.5 mm MMA caused selective and marked concentration-dependent depression of late force development (0.5 mm: approximately 60% of baseline, 1.5 mm: approximately 30% of baseline) with no alteration in early force development. MMA (1.5 mm) depressed rapid-cooling contracture to 53 +/- 10% of baseline, accompanied by approximately 63% prolongation of time to peak contracture. In patch clamp studies, MMA reduced I(Ca) in a concentration-dependent manner. CONCLUSIONS: The direct myocardial depressant effect of MMA seems to be caused in part by depression of Ca2+ influx through cardiac membrane, while depolarization-activated sarcoplasmic reticulum Ca2+ release appears modestly depressed.
Files in This Item:
T200304550.pdf Download
DOI
OAK-2003-00720
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Park, Wyun Kon(박윤곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113880
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