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Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis

 Bong-Kyeong Oh  ;  Kwang Jo Chae  ;  Young Nyun Park  ;  Kwang-hyub Han  ;  Woo Jung Lee  ;  Kyungsik Kim  ;  Chanil Park 
 JOURNAL OF HEPATOLOGY, Vol.39(5) : 786-792, 2003 
Journal Title
Issue Date
Adult ; Carcinoma, Hepatocellular/etiology* ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Chronic Disease ; Enzyme Activation ; Female ; Hepatitis/complications ; Hepatitis/enzymology ; Hepatitis/genetics ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/enzymology ; Liver Cirrhosis/genetics ; Liver Diseases/complications ; Liver Diseases/enzymology* ; Liver Diseases/genetics* ; Liver Diseases/pathology ; Liver Neoplasms/etiology* ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Polymorphism, Restriction Fragment Length ; Precancerous Conditions/complications ; Precancerous Conditions/enzymology* ; Precancerous Conditions/genetics* ; Precancerous Conditions/pathology ; Telomerase/metabolism* ; Telomere/genetics*
Telomere ; Telomerase ; Dysplastic nodule ; Hepatocellular carcinoma ; Large regenerative nodule ; Hepatocarcinogenesis ; Cirrhosis
BACKGROUNDS/AIMS: The maintenance of telomere with telomerase reactivation, vital for carcinogenesis, was studied in human multistep hepatocarcinogenesis for the characterization of borderline lesions. METHODS: The terminal restriction fragment length (TRFL) and telomerase activity (TA) were examined in 3 chronic hepatitis (CH), 10 cirrhosis, 7 large regenerative nodules (LRNs), 30 low grade dysplastic nodules (LGDNs), 6 high grade DNs (HGDNs), 3 DNs with hepatocellular carcinoma (HCC) foci, 11 HCCs, and 4 normal livers by Southern hybridization and TRAPeze Elisa telomerase detection. RESULTS: The TRFL and TA showed significant differences between the LGDNs and HGDNs. Most LGDNs had similar levels of TRFL and TA to those of the CH, cirrhosis and LRNs, however, 17% of LGDNs revealed shortening of telomeres up to the levels of HGDNs and 7% of LGDNs showed high levels of TA. The levels of TRFL and TA in HGDNs showed no significant differences from those of DNs with HCC foci and HCCs. CONCLUSIONS: The shortening of telomeres and reactivation of telomerase occur in the DNs during the early stages of hepatocarcinogenesis, with a significant change in the transition of LGDNs to HGDNs. The characteristics of HGDNs are considered to be closer to those of HCCs.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Chan Il(박찬일)
Oh, Bong Kyeong(오봉경)
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