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Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis

DC FieldValueLanguage
dc.contributor.author김경식-
dc.contributor.author박영년-
dc.contributor.author박찬일-
dc.contributor.author오봉경-
dc.date.accessioned2015-07-15T16:54:14Z-
dc.date.available2015-07-15T16:54:14Z-
dc.date.issued2003-
dc.identifier.issn0168-8278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/113829-
dc.description.abstractBACKGROUNDS/AIMS: The maintenance of telomere with telomerase reactivation, vital for carcinogenesis, was studied in human multistep hepatocarcinogenesis for the characterization of borderline lesions. METHODS: The terminal restriction fragment length (TRFL) and telomerase activity (TA) were examined in 3 chronic hepatitis (CH), 10 cirrhosis, 7 large regenerative nodules (LRNs), 30 low grade dysplastic nodules (LGDNs), 6 high grade DNs (HGDNs), 3 DNs with hepatocellular carcinoma (HCC) foci, 11 HCCs, and 4 normal livers by Southern hybridization and TRAPeze Elisa telomerase detection. RESULTS: The TRFL and TA showed significant differences between the LGDNs and HGDNs. Most LGDNs had similar levels of TRFL and TA to those of the CH, cirrhosis and LRNs, however, 17% of LGDNs revealed shortening of telomeres up to the levels of HGDNs and 7% of LGDNs showed high levels of TA. The levels of TRFL and TA in HGDNs showed no significant differences from those of DNs with HCC foci and HCCs. CONCLUSIONS: The shortening of telomeres and reactivation of telomerase occur in the DNs during the early stages of hepatocarcinogenesis, with a significant change in the transition of LGDNs to HGDNs. The characteristics of HGDNs are considered to be closer to those of HCCs.-
dc.description.statementOfResponsibilityopen-
dc.format.extent786~792-
dc.relation.isPartOfJOURNAL OF HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCarcinoma, Hepatocellular/etiology*-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChronic Disease-
dc.subject.MESHEnzyme Activation-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis/complications-
dc.subject.MESHHepatitis/enzymology-
dc.subject.MESHHepatitis/genetics-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/complications-
dc.subject.MESHLiver Cirrhosis/enzymology-
dc.subject.MESHLiver Cirrhosis/genetics-
dc.subject.MESHLiver Diseases/complications-
dc.subject.MESHLiver Diseases/enzymology*-
dc.subject.MESHLiver Diseases/genetics*-
dc.subject.MESHLiver Diseases/pathology-
dc.subject.MESHLiver Neoplasms/etiology*-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Restriction Fragment Length-
dc.subject.MESHPrecancerous Conditions/complications-
dc.subject.MESHPrecancerous Conditions/enzymology*-
dc.subject.MESHPrecancerous Conditions/genetics*-
dc.subject.MESHPrecancerous Conditions/pathology-
dc.subject.MESHTelomerase/metabolism*-
dc.subject.MESHTelomere/genetics*-
dc.titleTelomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorBong-Kyeong Oh-
dc.contributor.googleauthorKwang Jo Chae-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorKwang-hyub Han-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorKyungsik Kim-
dc.contributor.googleauthorChanil Park-
dc.identifier.doi10.1016/S0168-8278(03)00395-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA01563-
dc.contributor.localIdA01710-
dc.contributor.localIdA02369-
dc.relation.journalcodeJ01441-
dc.identifier.eissn1600-0641-
dc.identifier.pmid14568262-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0168827803003957-
dc.subject.keywordTelomere-
dc.subject.keywordTelomerase-
dc.subject.keywordDysplastic nodule-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordLarge regenerative nodule-
dc.subject.keywordHepatocarcinogenesis-
dc.subject.keywordCirrhosis-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Chan Il-
dc.contributor.alternativeNameOh, Bong Kyeong-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Chan Il-
dc.contributor.affiliatedAuthorOh, Bong Kyeong-
dc.rights.accessRightsnot free-
dc.citation.volume39-
dc.citation.number5-
dc.citation.startPage786-
dc.citation.endPage792-
dc.identifier.bibliographicCitationJOURNAL OF HEPATOLOGY, Vol.39(5) : 786-792, 2003-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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