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P-63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma

Authors
 Nam Hoon Cho  ;  Yong Bae Kim  ;  Ki Jun Song  ;  Kyeongmee Park  ;  Gwi Eon Kim  ;  Tchan Kyu Park 
Citation
 GYNECOLOGIC ONCOLOGY, Vol.91(2) : 346-353, 2003 
Journal Title
 GYNECOLOGIC ONCOLOGY 
ISSN
 0090-8258 
Issue Date
2003
MeSH
p63 ; EGFR ; Cervical carcinoma ; Radiotherapy with concurrent chemotherapy ; Prognostic factor
Keywords
p63 ; EGFR ; Cervical carcinoma ; Radiotherapy with concurrent chemotherapy ; Prognostic factor
Abstract
OBJECTIVES: The purpose of this study was to determine the relation between p63, p53-related gene, epidermal growth factor receptor (EGFR), and spontaneous apoptosis in relation to radiotherapy in patients with FIGO stage IIB cervical carcinoma, who had undergone radiation and concurrent chemotherapy, retrospectively. METHODS: Eighty-four patients with FIGO stage IIB squamous cell carcinoma (SCC) of the uterine cervix, who were treated with radiotherapy and concurrent chemotherapy between 1991 and 1996, were included in the present study. The clinicopathologic features, patterns of treatment failure, and survival data were compared with the expressions of p63 and EGFR, which were determined by immunohistochemistry and with apoptosis by TUNEL on tissue-arrayed slides. Univariate and multivariate analyses were performed to determine the prognostic factors that influence patient survival. RESULTS: Overall the indices of the expressions of p63 and EGFR in stage IIB cervical carcinoma were 18.7 and 26.6%, respectively, and these were found to be correlated. EGFR expression was significantly associated with extrapelvic failure (P = 0.03), whereas p63 was associated with locoregional failure (P = 0.03). The spontaneous apoptotic index showed no prognostic value, but the immunoreactivities of p63 and EGFR were associated with a worse prognosis by both univariate (P = 0.01 and 0.04, respectively) and multivariate analysis (95% CI:2.0-4.4, RR:3.2 and 95% CI:4.9-8.7, RR:6.7, respectively). CONCLUSIONS: The expression of p63 gene is associated with poor survival and locoregional failure, whereas EGFR expression was found to be a prognostic predictor of extrapelvic failure. Both molecules were found to be potent molecular risk factors in patients with FIGO stage IIB SCC of the uterine cervix, who had received radiotherapy and concurrent chemotherapy.
Full Text
http://www.sciencedirect.com/science/article/pii/S0090825803005043
DOI
10.1016/S0090-8258(03)00504-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113700
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