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국내에서 분리된 extended-spectrum β-lactamase 생성 Escherichia coli와 Klebsiella pneumoniae의 빈도 및 유형

Other Titles
 Prevalence & Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates in Korea 
 홍성근  ;  김선주  ;  정윤섭  ;  이경원  ;  용동은  ;  염종화  ;  어영  ;  송원근  ;  이혜수  ;  신종희  ;  안지영  ;  조성란  ;  장철훈  ;  정석훈 
 Korean Journal of Clinical Microbiology (대한임상미생물학회지), Vol.6(2) : 149-155, 2003 
Journal Title
 Korean Journal of Clinical Microbiology (대한임상미생물학회지) 
Issue Date
Extended-spectrum -lactamase (ESBL) ; Escherichia coli ; Klebsiella pneumoniae
Extended-spectrum -lactamase (ESBL) ; Escherichia coli ; Klebsiella pneumoniae
Background : Increase in extended-spectrum p-lactamase(ESBL)-producing Escherichia coli and Klebsiella pneumoniae have beeh reported in Korea. The aim of this study was to determine the na¬tionwide prevalence of ESBL-producing E. coli and K pneumoniae, and to investigate the types of ESBLs. Methods : A total of 2,221 E. coli and 11,128 K pneumoniae consecutive isolates were yearly col¬lected from 12 hospitals in 1999 and 2000. ESBL production was performed by National Committee for Clinical Laboratory Standards methods and double synergy tests. The type of ESBL was deter¬mined by polymerase chain reaction (PCR), isoelectric focusing, and nucleotide sequence analysis. Results: ESBL-producing E. coli and K pneumoniae isolates were detected from all 12 hospitals participated. The proportion of ESBL-producers was 9.1%(2.0-19.6%) of the E. coli and 29.2% (10.0-60.8%) of the K pneumoniae isolates. Among the 22 isolates sequenced, SHV-12 was found in six isolates, SHV-2a in three isolates, TEM-52 in five isolates, TEM-106 in three isolates, and each of TEM-15, TEM-20, TEM-43, and TEM-107 in one isolate. CTX-M-14 was also found in one isolate. Conclusion: ESBL-producing E. coli and K pneumoniae are widespred to all levels of Korean hospitals. The most common types of ESBLs in Korea are SHV-12, SHV-2a, and TEM-52. In addition, we also identified new TEM-derived ESBLs.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Institute of Bacterial Resistance (세균내성연구소) > 1. Journal Papers
Yonsei Authors
Yum, Jong Hwa(염종화)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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