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급성백혈병 환자에서 관해유도 항암화학요법 후 발생한 호중구감소증에 대한 류코카인의 효과 : 전향적 이중 비교의 다기관 임상연구

Other Titles
 Effect of Leukokine in Patients with Acute Leukemia Receiving Induction Chemotherapy 
 김선영  ;  장필상  ;  이규형  ;  황태주  ;  양창현  ;  유철주  ;  안효섭  ;  신희영  ;  최형수  ;  강형진  ;  이건수  ;  김학기  ;  조빈  ;  정대철  ;  정낙균 
 Korean Journal of Pediatric Hematology-Oncology (대한소아혈액종양학회지), Vol.10(2) : 206-213, 2003 
Journal Title
Korean Journal of Pediatric Hematology-Oncology(대한소아혈액종양학회지)
Issue Date
Acute leukemia ; Leukokine ; Grasin
Acute leukemia ; Leukokine ; Grasin
Purpose: Neutropenia is common in patients receiving myelotoxic chemotherapy. The aim of this study is to compare the efficacy, safety and adverse events between prophylactically administered Leukokine and Grasin .

Methods: An open-label, randomized, phase III study was designed to compare the effects of a subcutaneous injection of Leukokine (CJ Corp.) 100mug/m2 with Grasin (Jeil Pharm. Inc.) in patients receiving induction chemotherapy for acute leukemia. All patients received one dose of G-CSF every day during the study period. Total period of G-CSF injection was not over 14 days. The administration of G-CSF began on day 14 after beginning of chemotherapy under CCG strategy. In other chemotherapies, the injection of G-CSF started on day 1 from end of chemotherapy. Injection of G-CSF stopped after absolute neutrophil count recovery was achieved.

Results: The median numbers of times of administration were 9.6(2~14)/cycle for Leukokine and 8.8 (2~14)/cycle for Grasin . The time to needed for neutrophil recovery more than 1,000/mm3 was 6.6 4.9 day and 4.7 4.8 day of the Leukokine and Grasin , respectively (P=0.14). The mean duration of neutropenia less than 500/mm3 was 7.6 5.6 days for Leukokine and 6.1 6.0 days for Grasin (P=0.28). The results for the two groups were also not significantly different in adverse events, physical examination and laboratory findings.

Conclusion: Leukokine was safe and well tolerated in these patients population. Injection of Leukokine provided neutrophil recovery with safety and efficacy similar to that provided by Grasin.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
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