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급성백혈병 환자에서 관해유도 항암화학요법 후 발생한 호중구감소증에 대한 류코카인의 효과 : 전향적 이중 비교의 다기관 임상연구

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dc.contributor.author유철주-
dc.date.accessioned2015-07-15T16:48:58Z-
dc.date.available2015-07-15T16:48:58Z-
dc.date.issued2003-
dc.identifier.issn2233-5250-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/113654-
dc.description.abstractPurpose: Neutropenia is common in patients receiving myelotoxic chemotherapy. The aim of this study is to compare the efficacy, safety and adverse events between prophylactically administered Leukokine and Grasin . Methods: An open-label, randomized, phase III study was designed to compare the effects of a subcutaneous injection of Leukokine (CJ Corp.) 100mug/m2 with Grasin (Jeil Pharm. Inc.) in patients receiving induction chemotherapy for acute leukemia. All patients received one dose of G-CSF every day during the study period. Total period of G-CSF injection was not over 14 days. The administration of G-CSF began on day 14 after beginning of chemotherapy under CCG strategy. In other chemotherapies, the injection of G-CSF started on day 1 from end of chemotherapy. Injection of G-CSF stopped after absolute neutrophil count recovery was achieved. Results: The median numbers of times of administration were 9.6(2~14)/cycle for Leukokine and 8.8 (2~14)/cycle for Grasin . The time to needed for neutrophil recovery more than 1,000/mm3 was 6.6 4.9 day and 4.7 4.8 day of the Leukokine and Grasin , respectively (P=0.14). The mean duration of neutropenia less than 500/mm3 was 7.6 5.6 days for Leukokine and 6.1 6.0 days for Grasin (P=0.28). The results for the two groups were also not significantly different in adverse events, physical examination and laboratory findings. Conclusion: Leukokine was safe and well tolerated in these patients population. Injection of Leukokine provided neutrophil recovery with safety and efficacy similar to that provided by Grasin.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfKorean Journal of Pediatric Hematology-Oncology (대한소아혈액종양학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute leukemia-
dc.subject.MESHLeukokine-
dc.subject.MESHGrasin-
dc.title급성백혈병 환자에서 관해유도 항암화학요법 후 발생한 호중구감소증에 대한 류코카인의 효과 : 전향적 이중 비교의 다기관 임상연구-
dc.title.alternativeEffect of Leukokine in Patients with Acute Leukemia Receiving Induction Chemotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthor김선영-
dc.contributor.googleauthor장필상-
dc.contributor.googleauthor이규형-
dc.contributor.googleauthor황태주-
dc.contributor.googleauthor양창현-
dc.contributor.googleauthor유철주-
dc.contributor.googleauthor안효섭-
dc.contributor.googleauthor신희영-
dc.contributor.googleauthor최형수-
dc.contributor.googleauthor강형진-
dc.contributor.googleauthor이건수-
dc.contributor.googleauthor김학기-
dc.contributor.googleauthor조빈-
dc.contributor.googleauthor정대철-
dc.contributor.googleauthor정낙균-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ02096-
dc.subject.keywordAcute leukemia-
dc.subject.keywordLeukokine-
dc.subject.keywordGrasin-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number2-
dc.citation.startPage206-
dc.citation.endPage213-
dc.identifier.bibliographicCitationKorean Journal of Pediatric Hematology-Oncology (대한소아혈액종양학회지), Vol.10(2) : 206-213, 2003-
dc.identifier.rimsid44821-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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