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Panipenem의 임상검체에서 분리된 호기성 및 혐기성 세균에 대한 시험관내 항균력

Other Titles
 In Vitro Activities of Panipenem against Clinical Isolates of Aerobic and Anaerobic Bacteria 
Authors
 이경원  ;  이운형  ;  이노우에 마쓰히사  ;  오카도모 료이치  ;  정윤섭  ;  염종화  ;  용동은 
Citation
 Infection and Chemotherapy (감염과 화학요법), Vol.35(6) : 423-433, 2003 
Journal Title
 Infection and Chemotherapy  (감염과 화학요법) 
ISSN
 1598-8112 
Issue Date
2003
Abstract
Background:Panipenem is a carbapenem antimicrobial agent which has been shown to have broad-spectrum activities against various aerobic and anaerobic bacteria. In this study, in vitro activities of panipenem against recent clinical isolates of aerobic and anaerobic bacteria were determined. Methods:Aerobic and anaerobic bacteria were isolated in 2001 and in 2000-2001, respectively, from a tertiary-care hospital patients. Antimicrobial susceptibility was tested by the NCCLS agar dilution method. Results:MIC90s of panipenem were:similar to those of imipenem for aerobic gram-positive cocci and Enterobacteriaceae; slightly lower than those of meropenem for gram-positive cocci, but slightly higher for Enterobacteriaceae; slightly higher than imipenem for A. baumannii, but similar for anaerobic bacteria. Conclusion:MIC90s of panipenem were similar to those of imipenem for aerobic and anaerobic bacterial isolates, which frequently involve respiratory, urinary, intraabdominal and wound infections. When imipenem breakpoints are applied to interpret panipenem susceptibilities, panipenem can be considered useful for the treatment of various infections, including nosocomially acquired ones.
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Appears in Collections:
5. Research Institutes (연구소) > Research Institute of Bacterial Resistance (세균내성연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yum, Jong Hwa(염종화)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113426
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