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조기 알츠하이머 치매의 뇌포도당 대사 감소 평가에서 오류발견률 조절법의 적용

Other Titles
 Application of False Discovery Rate Control in the Assessment of Decrease of FDG Uptake in Early Alzheimer Dementia 
Authors
 이동수  ;  강혜진  ;  이명철  ;  우종인  ;  이강욱  ;  강은주  ;  이재성  ;  강원준  ;  조상수  ;  장명진 
Citation
 NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.37(6) : 374-381, 2003 
Journal Title
NUCLEAR MEDICINE AND MOLECULAR IMAGING(핵의학 분자영상)
ISSN
 1869-3474 
Issue Date
2003
MeSH
false discovery rate ; Alzheimer dementia ; FDG uptake ; statistical parametric mapping
Keywords
false discovery rate ; Alzheimer dementia ; FDG uptake ; statistical parametric mapping
Abstract
Purpose: Determining an appropriate thresholding is crucial for PDG PET analysis since strong control of Type I error could fail to find pathological differences between early Alzheimer´ disease (AD) patients and healthy normal controls. We compared the SPM results on FDG PET imaging of early AD using uncorrected p-value, random-field based corrected p-value and false discovery rate (FDR) control. Materials and Methods: Twenty-eight patients (66±7 years old) with early AD and 18 age-matched normal controls (68±6 years old) underwent FDG brain PET. To identify brain regions with hypo-metabolism in group or individual patient compared to normal controls, group images or each patient´s image was compared with normal controls usingthe same fixed p-value of 0.001 on uncorrected thresholding, random-field based corrected thresholding and FDR control. Results: The number of hypo-metabolic voxels was smallest in corrected p-value method, largest in uncorrected p-value method and intermediate in FDG thresholding in group analysis. Three types of result pattern were found. The first was that corrected p-value did not yield any voxel positive but FDR gave a few significantly hypometabolic voxels (8/28, 29%). The second was that both corrected p-value and FDR did not yield any positive region but numerous positive voxels were found with the threshold of uncorrected p-values (6/28, 21%). The last was that FDR was detected as many positive voxels as uncorrected p-value method (14/28, 50%). Conclusions FDR control could identify hypo-metabolic areas in group or individual patients with early AD. We recommend FDR control instead of uncorrected or random-field corrected thresholding method to find the areas showing hypometabolism especially in small group or individual analysis of FDG PET.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113366
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