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조기 알츠하이머 치매의 뇌포도당 대사 감소 평가에서 오류발견률 조절법의 적용
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dc.contributor.author | 강원준 | - |
dc.date.accessioned | 2015-07-15T16:40:21Z | - |
dc.date.available | 2015-07-15T16:40:21Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113366 | - |
dc.description.abstract | Purpose: Determining an appropriate thresholding is crucial for PDG PET analysis since strong control of Type I error could fail to find pathological differences between early Alzheimer´ disease (AD) patients and healthy normal controls. We compared the SPM results on FDG PET imaging of early AD using uncorrected p-value, random-field based corrected p-value and false discovery rate (FDR) control. Materials and Methods: Twenty-eight patients (66±7 years old) with early AD and 18 age-matched normal controls (68±6 years old) underwent FDG brain PET. To identify brain regions with hypo-metabolism in group or individual patient compared to normal controls, group images or each patient´s image was compared with normal controls usingthe same fixed p-value of 0.001 on uncorrected thresholding, random-field based corrected thresholding and FDR control. Results: The number of hypo-metabolic voxels was smallest in corrected p-value method, largest in uncorrected p-value method and intermediate in FDG thresholding in group analysis. Three types of result pattern were found. The first was that corrected p-value did not yield any voxel positive but FDR gave a few significantly hypometabolic voxels (8/28, 29%). The second was that both corrected p-value and FDR did not yield any positive region but numerous positive voxels were found with the threshold of uncorrected p-values (6/28, 21%). The last was that FDR was detected as many positive voxels as uncorrected p-value method (14/28, 50%). Conclusions FDR control could identify hypo-metabolic areas in group or individual patients with early AD. We recommend FDR control instead of uncorrected or random-field corrected thresholding method to find the areas showing hypometabolism especially in small group or individual analysis of FDG PET. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | false discovery rate | - |
dc.subject.MESH | Alzheimer dementia | - |
dc.subject.MESH | FDG uptake | - |
dc.subject.MESH | statistical parametric mapping | - |
dc.title | 조기 알츠하이머 치매의 뇌포도당 대사 감소 평가에서 오류발견률 조절법의 적용 | - |
dc.title.alternative | Application of False Discovery Rate Control in the Assessment of Decrease of FDG Uptake in Early Alzheimer Dementia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학) | - |
dc.contributor.googleauthor | 이동수 | - |
dc.contributor.googleauthor | 강혜진 | - |
dc.contributor.googleauthor | 이명철 | - |
dc.contributor.googleauthor | 우종인 | - |
dc.contributor.googleauthor | 이강욱 | - |
dc.contributor.googleauthor | 강은주 | - |
dc.contributor.googleauthor | 이재성 | - |
dc.contributor.googleauthor | 강원준 | - |
dc.contributor.googleauthor | 조상수 | - |
dc.contributor.googleauthor | 장명진 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00062 | - |
dc.relation.journalcode | J02383 | - |
dc.identifier.eissn | 1869-3482 | - |
dc.subject.keyword | false discovery rate | - |
dc.subject.keyword | Alzheimer dementia | - |
dc.subject.keyword | FDG uptake | - |
dc.subject.keyword | statistical parametric mapping | - |
dc.contributor.alternativeName | Kang, Won Jun | - |
dc.contributor.affiliatedAuthor | Kang, Won Jun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 374 | - |
dc.citation.endPage | 381 | - |
dc.identifier.bibliographicCitation | NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.37(6) : 374-381, 2003 | - |
dc.identifier.rimsid | 55861 | - |
dc.type.rims | ART | - |
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