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Biocompatibility and charge injection property of iridium film formed by ion beam assisted deposition

Authors
 In-Seop Lee  ;  Chung-Nam Whang  ;  Won-Sun Seo  ;  Dong-Hee Lee  ;  Jong-Chul Park 
Citation
 BIOMATERIALS, Vol.24(13) : 2225-2231, 2003 
Journal Title
 BIOMATERIALS 
ISSN
 0142-9612 
Issue Date
2003
MeSH
Animals ; Cell Adhesion/drug effects ; Cell Adhesion/physiology ; Cell Division/drug effects ; Cell Division/physiology ; Coated Materials, Biocompatible/chemical synthesis* ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/pharmacology ; Electric Stimulation/instrumentation* ; Electric Stimulation/methods ; Electric Stimulation Therapy/instrumentation ; Electric Stimulation Therapy/methods ; Electrochemistry ; Electrodes, Implanted* ; Electroplating/methods* ; Iridium/chemistry* ; Iridium/pharmacology ; Materials Testing ; Neurons/drug effects ; Neurons/physiology* ; PC12 Cells ; Rats ; Static Electricity
Keywords
Ir film ; Neural electrode ; Stimulation ; IBAD ; PC12 cell
Abstract
Iridium thin film formed by electron-beam evaporation with simultaneous bombardment of Ar ion beam was evaluated for a stimulating neural electrode. The electrochemical behavior of as-deposited Ir film on Ni–Ti sample was almost identical to bulk Ir by producing much higher open-circuit corrosion potential and much lower anodic current density than the uncoated Ni–Ti in both 1 n sulfuric acid and saline solution. The charge injection capability of Ir film was compared with that of Pt electrode currently used mostly as a stimulating neural electrode. The charge density of Pt was small and unchanged with increasing number of activating cycles in 0.1 m H2SO4, whilst the Ir film continuously produced increases in charge density. The charge injection density of Ir film in physiological solution was higher for the more activated sample under the identical stimulating condition. Attachment and proliferation with PC12 cells on Ir-coated CP Ti without applying electrical stimulation was similar to the polished CP Ti. A network of neurons and extending axons were formed on Ir film.
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961203000255
DOI
10.1016/S0142-9612(03)00025-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113357
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