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관상동맥우회술 환자의 마취유도시 Fentanyl과 Vecuronium 사용으로 발생하는 서맥에 대한 Atropine의 약물 효과

Other Titles
 Effects of Preinduction Atropine on the Hemody namic Response to Induction with Fentanyl and Vecuronium for Coronary Artery Bypass Grafting 
Authors
 곽현정  ;  이우경  ;  곽영란  ;  박근모 
Citation
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.44(5) : 626-632, 2003 
Journal Title
 Journal of Korean Society of Anesthesiologist (대한마취과학회지) 
ISSN
 0302-5780 
Issue Date
2003
MeSH
Atropine ; bradycardia ; coronary artery bypass graft surgery ; fentanyl ; vecuronium
Keywords
Atropine ; bradycardia ; coronary artery bypass graft surgery ; fentanyl ; vecuronium
Abstract
Background: Induction of anesthesia with a high dose of fentanyl and vecuronium decreases the heart rate and blood pressure. This study was designed to evaluate the effect of preinduction atropine on these hemodynamic changes in patients undergoing coronary artery bypass graft surgery (CABG). Methods: Forty-one patients who underwent CABG were randomly divided into two groups. After insertion of a radial artery cannula and a Swan-Ganz catheter, normal saline 1 ml (control group, n = 20) or atropine 0.5 mg (atropine group, n = 21) was injected intravenously 1 min before the induction of anesthesia. Anesthesia was induced with a first dose of fentanyl (5-8μg/ kg) and vecuronium (0.12 mg/kg) and a second dose of fentanyl (5-10μg/kg). The patient was then intubated. Hemodynamic variables were measured before the induction of anesthesia, 1 min after the administration of each drug during the induction of anesthesia and 5, 10, and 30 min after the intubation. Results: There was no significant differences between the two groups in terms of demographic data except that the number of patients with diabetes mellitus was greater in the control group than in the atropine group. The number of patients treated for hypotension or bradycardia during the induction of anesthesia was greater in the control group than in the atropine group, but this was not statistically significant. Heart rates significantly decreased in the control group but were maintained in the atropine group without any significant tachycardia. Blood pressure significantly decreased in both groups. Conclusions: Intravenous injection of atropine before anesthetic induction in patients undergoing CABG attenuates the decrease in heart rate resulting from anesthetic induction with high dose fentanyl and vecuronium. However, it didn't prevent the decrease in blood pressure nor did it reduce the incidence of treatment for hypotension.
Files in This Item:
T200302229.pdf Download
DOI
OAK-2003-00122
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kwak, Hyun Jeong(곽현정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113282
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