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Clinical Features of Pulmonary Large Cell Neuroendocrine Carcinoma

 Moo Suk Park  ;  Kil Dong Kim  ;  Joon Chang  ;  Sung Kyu Kim  ;  Chul Min Ahn  ;  Se Kyu Kim  ;  Hyung Joong Kim  ;  Young Sam Kim  ;  Chang Yul Lee  ;  Joo Hang Kim  ;  Kyung Young Chung  ;  Dong Hwan Shin  ;  Jae Ho Chung 
 CANCER RESEARCH AND TREATMENT, Vol.35(3) : 245-253, 2003 
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Lung neoplasm ; Large cell ; Carcinoma ; Neuroendocrine tumor
Lung neoplasm ; Large cell ; Carcinoma ; Neuroendocrine tumor
PURPOSE: This study was performed to investigate the clinical features of large cell neuroendocrine carcinomas (LCNEC). MATERIALS AND METHODS: We retrospectively reviewed the histopathology and clinical information of 37 patients with LCNEC, diagnosed between June 1992 and May 2002 at the Severance Hospital, and performed immunohistochemical (IHC) staining. RESULTS: The prevalence of LCNEC among primary lung cancers was 0.3%, 37 out of 13, 012 cases over a 10 year period. The mean age was 61+/-12 years old, with 34 (92%) males and 3 (8%) females. 30 patients smoked, with an average of 42 packs per year. A cough was the most frequent symptom. The tumor was located at the periphery of the lung in 24 cases (65%). Among the 30 cases that underwent surgery, 4 were diagnosed pathological stage IA, 11 IB, 1 IIB, 13 IIIA and 1 IIIB. The 7 clinically non-operable cases were IIIB in 3, and IV in 4. The positive rates of CD56, thyroid transcription factor-1 (TTF-1), chromogranin A, synaptophysin and 34betaE12 for tumor cells were 88.9, 55.6, 42.1, 31.6 and 21.1%, respectively, from the IHC staining. The median survival time and 5 year-survival rate were 24 months and 27%, respectively. The group that underwent surgery had a better prognosis than those that did not. CONCLUSION: The positive rates for the tumor markers varied, but those of the CD56 and TFT-1 were the highest. The possibility of LCNEC needs to be evaluated for the following situations: small cell carcinomas located at the periphery and not responding chemotherapy, small cell carcinomas diagnosed by percutaneous needle aspiration, poorly differentiated non-mall cell carcinomas, with uncertain histologic type, and unclassified neuroendocrine tumor, etc.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyu(김세규)
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
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