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Clinical Features of Pulmonary Large Cell Neuroendocrine Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김세규 | - |
dc.contributor.author | 김형중 | - |
dc.contributor.author | 박무석 | - |
dc.date.accessioned | 2015-07-15T16:36:48Z | - |
dc.date.available | 2015-07-15T16:36:48Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113248 | - |
dc.description.abstract | PURPOSE: This study was performed to investigate the clinical features of large cell neuroendocrine carcinomas (LCNEC). MATERIALS AND METHODS: We retrospectively reviewed the histopathology and clinical information of 37 patients with LCNEC, diagnosed between June 1992 and May 2002 at the Severance Hospital, and performed immunohistochemical (IHC) staining. RESULTS: The prevalence of LCNEC among primary lung cancers was 0.3%, 37 out of 13, 012 cases over a 10 year period. The mean age was 61+/-12 years old, with 34 (92%) males and 3 (8%) females. 30 patients smoked, with an average of 42 packs per year. A cough was the most frequent symptom. The tumor was located at the periphery of the lung in 24 cases (65%). Among the 30 cases that underwent surgery, 4 were diagnosed pathological stage IA, 11 IB, 1 IIB, 13 IIIA and 1 IIIB. The 7 clinically non-operable cases were IIIB in 3, and IV in 4. The positive rates of CD56, thyroid transcription factor-1 (TTF-1), chromogranin A, synaptophysin and 34betaE12 for tumor cells were 88.9, 55.6, 42.1, 31.6 and 21.1%, respectively, from the IHC staining. The median survival time and 5 year-survival rate were 24 months and 27%, respectively. The group that underwent surgery had a better prognosis than those that did not. CONCLUSION: The positive rates for the tumor markers varied, but those of the CD56 and TFT-1 were the highest. The possibility of LCNEC needs to be evaluated for the following situations: small cell carcinomas located at the periphery and not responding chemotherapy, small cell carcinomas diagnosed by percutaneous needle aspiration, poorly differentiated non-mall cell carcinomas, with uncertain histologic type, and unclassified neuroendocrine tumor, etc. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Lung neoplasm | - |
dc.subject.MESH | Large cell | - |
dc.subject.MESH | Carcinoma | - |
dc.subject.MESH | Neuroendocrine tumor | - |
dc.title | Clinical Features of Pulmonary Large Cell Neuroendocrine Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Kil Dong Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Sung Kyu Kim | - |
dc.contributor.googleauthor | Chul Min Ahn | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Hyung Joong Kim | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Chang Yul Lee | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.contributor.googleauthor | Dong Hwan Shin | - |
dc.contributor.googleauthor | Jae Ho Chung | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A01158 | - |
dc.contributor.localId | A01457 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.subject.keyword | Lung neoplasm | - |
dc.subject.keyword | Large cell | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | Neuroendocrine tumor | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 245 | - |
dc.citation.endPage | 253 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.35(3) : 245-253, 2003 | - |
dc.identifier.rimsid | 54235 | - |
dc.type.rims | ART | - |
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