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직업성 무, 배추 꽃가루병에 대한 조사

Other Titles
 Occupational Pollinosis Induced by Radish and Chinese Cabbage Pollens 
 권나영  ;  이재현  ;  홍천수  ;  박중원  ;  최수영 
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.24(3) : 288-293, 2004 
Journal Title
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) 
Issue Date
Occupational pollinosis ; Radish ; Cabbage
BACKGROUND: The Korean National Horticultural Research Institute (KNHRI) supplies many seeds for horticulturus farmers. The seeds of radish (Raphnus sativus acanthiformis) or Chinese cabbage (Brassica campestris pekinensis; cabbage) is one of their major products, and many employees have been exposed to these pollens occupationally. OBJECTIVE: We reviewed the questionnaires for allergic diseases and occupational history. We evaluated the prevalence of the sensitization to radish and cabbage pollens in the workers of KNHRI and analyzed the allergenicity of radish and cabbage pollens. METHOD: Fifty-fuve employees of KNHRI were enrolled in this study. Among them, 12 workers dealed with radish and cabbage pollens directly and were involved in the process of breeding these pollens. The skin prick test with extracts of radish and cabbage pollens and 12 common inhalant allergens were performed. Specific IgEs (sIgE) were detected by ELISA and immunoblotting. Cross-reactivity was determined through inhibition ELISA. RESULT: About 20% of the 55 workers showed positive response to radish and/or cabbage pollens. sixty-six percent of the direct exposed workers and 6.9% of the non-exposed workers showed positive responses to radish and/or cabbage pollens. Prevalence of allergic diseases was 56.4% in the workers. sIgE to radish and cabbage pollens were detected in 50% of exposed workers by ELISA. IgE immunoblotting showed sIgE binding at 24kD, 19kD, 9kD, and 8kD proteins of radish. sIgE also bound to 49kD, 36kD, 24kD, 19kD, and 9kD. Strong cross-allergenecity was found between radish and cabbage extracts on ELISA inhibition. CONCLUSION: Radish and cabbage pollens are significant occupational allergens to the exposed workers of KNHRI. Personal protective devices should be required for these workers.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Lee, Jae Hyun(이재현) ORCID logo https://orcid.org/0000-0002-0760-0071
Choi, Soo Young(최수영)
Hong, Chein Soo(홍천수)
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