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Sequential Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 during DMBA-induced Hamster Buccal Pouch Carcinogenesis

Authors
 SOO-A KIM  ;  SANG-GUN AHN  ;  JUNG HOON YOON  ;  JIN KIM  ;  SANG HO LEE  ;  SU GWAN KIM  ;  DO KYUNG KIM 
Citation
 IN VIVO, Vol.18(5) : 609-614, 2004 
Journal Title
 IN VIVO 
ISSN
 0258-851X 
Issue Date
2004
MeSH
9,10-Dimethyl-1,2-benzanthracene/toxicity ; Animals ; Biomarkers, Tumor/metabolism ; Carcinogens/toxicity ; Carcinoma in Situ/chemically induced ; Carcinoma in Situ/enzymology* ; Carcinoma in Situ/pathology ; Carcinoma, Squamous Cell/chemically induced ; Carcinoma, Squamous Cell/enzymology* ; Carcinoma, Squamous Cell/pathology ; Cricetinae ; Cyclooxygenase 2 ; Disease Models, Animal ; Immunoenzyme Techniques ; Isoenzymes/metabolism* ; Male ; Mesocricetus ; Mouth Neoplasms/chemically induced ; Mouth Neoplasms/enzymology* ; Mouth Neoplasms/pathology ; Nitric Oxide Synthase/biosynthesis* ; Nitric Oxide Synthase Type II ; Precancerous Conditions/chemically induced ; Precancerous Conditions/enzymology* ; Precancerous Conditions/pathology ; Prostaglandin-Endoperoxide Synthases/metabolism*
Keywords
iNOS ; COX-2 ; oral cancer ; DMBA ; hamster buccal pouch carcinoma model ; carcinogenesis
Abstract
BACKGROUND: Although it is known that iNOS and COX-2 are abundantly expressed in oral premalignant and malignant lesions, respectively, the interaction between iNOS and COX-2 has not been extensively studied. The purpose of this study was to examine the alteration of the iNOS and COX-2 expression level during hamster buccal pouch (HBP) carcinogenesis. MATERIALS AND METHODS: The expression of both iNOS and COX-2 on normal, dysplastic mucosa and squamous cell carcinoma (SCC) from different differentiation stages in 7, 12-dimethylbenz[a]anthracene (DMBA)-induced HBP carcinogenesis was examined using immunohistochemical analysis. RESULTS: The mean values of both iNOS and COX-2 expression increased gradually from control to dysplastic lesions and more to invasive SCC. The highest mean expression was SCC. The differences between both iNOS and COX-2 expression in the normal and that in the dysplastic and carcinoma lesions were statistically significant. CONCLUSION: The results suggest that iNOS can enhance its ability to promote tumor growth in cooperation with COX-2. The expression of iNOS and COX-2 may be one of the factors that contribute to oral carcinogenesis.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112799
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