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Sequential Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 during DMBA-induced Hamster Buccal Pouch Carcinogenesis
DC Field | Value | Language |
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dc.contributor.author | 김진 | - |
dc.date.accessioned | 2015-07-14T17:23:51Z | - |
dc.date.available | 2015-07-14T17:23:51Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112799 | - |
dc.description.abstract | BACKGROUND: Although it is known that iNOS and COX-2 are abundantly expressed in oral premalignant and malignant lesions, respectively, the interaction between iNOS and COX-2 has not been extensively studied. The purpose of this study was to examine the alteration of the iNOS and COX-2 expression level during hamster buccal pouch (HBP) carcinogenesis. MATERIALS AND METHODS: The expression of both iNOS and COX-2 on normal, dysplastic mucosa and squamous cell carcinoma (SCC) from different differentiation stages in 7, 12-dimethylbenz[a]anthracene (DMBA)-induced HBP carcinogenesis was examined using immunohistochemical analysis. RESULTS: The mean values of both iNOS and COX-2 expression increased gradually from control to dysplastic lesions and more to invasive SCC. The highest mean expression was SCC. The differences between both iNOS and COX-2 expression in the normal and that in the dysplastic and carcinoma lesions were statistically significant. CONCLUSION: The results suggest that iNOS can enhance its ability to promote tumor growth in cooperation with COX-2. The expression of iNOS and COX-2 may be one of the factors that contribute to oral carcinogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 609~614 | - |
dc.relation.isPartOf | IN VIVO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 9,10-Dimethyl-1,2-benzanthracene/toxicity | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Carcinogens/toxicity | - |
dc.subject.MESH | Carcinoma in Situ/chemically induced | - |
dc.subject.MESH | Carcinoma in Situ/enzymology* | - |
dc.subject.MESH | Carcinoma in Situ/pathology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/chemically induced | - |
dc.subject.MESH | Carcinoma, Squamous Cell/enzymology* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Cricetinae | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Immunoenzyme Techniques | - |
dc.subject.MESH | Isoenzymes/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesocricetus | - |
dc.subject.MESH | Mouth Neoplasms/chemically induced | - |
dc.subject.MESH | Mouth Neoplasms/enzymology* | - |
dc.subject.MESH | Mouth Neoplasms/pathology | - |
dc.subject.MESH | Nitric Oxide Synthase/biosynthesis* | - |
dc.subject.MESH | Nitric Oxide Synthase Type II | - |
dc.subject.MESH | Precancerous Conditions/chemically induced | - |
dc.subject.MESH | Precancerous Conditions/enzymology* | - |
dc.subject.MESH | Precancerous Conditions/pathology | - |
dc.subject.MESH | Prostaglandin-Endoperoxide Synthases/metabolism* | - |
dc.title | Sequential Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 during DMBA-induced Hamster Buccal Pouch Carcinogenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | SOO-A KIM | - |
dc.contributor.googleauthor | SANG-GUN AHN | - |
dc.contributor.googleauthor | JUNG HOON YOON | - |
dc.contributor.googleauthor | JIN KIM | - |
dc.contributor.googleauthor | SANG HO LEE | - |
dc.contributor.googleauthor | SU GWAN KIM | - |
dc.contributor.googleauthor | DO KYUNG KIM | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01009 | - |
dc.relation.journalcode | J01043 | - |
dc.identifier.eissn | 1791-7549 | - |
dc.identifier.pmid | 15523901 | - |
dc.subject.keyword | iNOS | - |
dc.subject.keyword | COX-2 | - |
dc.subject.keyword | oral cancer | - |
dc.subject.keyword | DMBA | - |
dc.subject.keyword | hamster buccal pouch carcinoma model | - |
dc.subject.keyword | carcinogenesis | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 609 | - |
dc.citation.endPage | 614 | - |
dc.identifier.bibliographicCitation | IN VIVO, Vol.18(5) : 609-614, 2004 | - |
dc.identifier.rimsid | 44514 | - |
dc.type.rims | ART | - |
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