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Epidemiological characteristics and molecular basis of fluoroquinolone-resistant Neisseria gonorrhoeae strains isolated in Korea and nearby countries

Authors
 Dongeun Yong  ;  Tae Sook Kim  ;  John W. Tapsall  ;  Tiffany Shultz  ;  Hee-Bok Oh  ;  Yunsop Chong  ;  Kyungwon Lee  ;  Jong Hwa Yum  ;  Jong Rak Choi 
Citation
 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.54(2) : 451-455, 2004 
Journal Title
 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 
ISSN
 0305-7453 
Issue Date
2004
MeSH
Amino Acid Substitution ; Anti-Infective Agents/pharmacology* ; Ciprofloxacin/pharmacology ; DNA Gyrase/genetics ; DNA Mutational Analysis ; DNA Topoisomerase IV/genetics ; Electrophoresis, Gel, Pulsed-Field ; Fluoroquinolones/pharmacology* ; Gonorrhea/epidemiology* ; Gonorrhea/microbiology* ; Humans ; Korea/epidemiology ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Neisseria gonorrhoeae/drug effects* ; Neisseria gonorrhoeae/genetics*
Keywords
N. gonorrhoeae ; pulsed-field gel electrophoresis ; ciprofloxacin ; resistance ; QRDRs
Abstract
OBJECTIVES: This study was performed to examine the cause of the increase in quinolone-resistant Neisseria gonorrhoeae (QRNG) observed in Korea. METHODS: The antimicrobial susceptibilities of 190 isolates of gonococci from Korea in 2000 were examined by NCCLS methods, and subsets of these isolates underwent mutation analysis of the quinolone resistance-determining regions (QRDRs) of gyrA and parC. Molecular epidemiological characterization of 25 Korean isolates and 54 isolates from overseas was performed by pulsed-field gel electrophoresis (PFGE) and the results compared. RESULTS: Most (172, 90.5%) of the 190 gonococci tested displayed reduced susceptibility to ciprofloxacin. All strains with high-level ciprofloxacin resistance (ciprofloxacin MIC >/= 4 mg/L) contained a double amino acid alteration at the 91 and 95 positions in the QRDR of GyrA and a single alteration in ParC. PFGE types of high-level QRNG in Korea were mostly different from those of other nearby countries. CONCLUSIONS: These results suggest that the observed increase in ciprofloxacin-resistant isolates is due to the mutation and spread of Korean multiclonal isolates rather than importation from overseas.
Files in This Item:
T200401714.pdf Download
DOI
10.1093/jac/dkh345
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112775
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