Cited 19 times in
Epidemiological characteristics and molecular basis of fluoroquinolone-resistant Neisseria gonorrhoeae strains isolated in Korea and nearby countries
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-07-14T17:23:08Z | - |
dc.date.available | 2015-07-14T17:23:08Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112775 | - |
dc.description.abstract | OBJECTIVES: This study was performed to examine the cause of the increase in quinolone-resistant Neisseria gonorrhoeae (QRNG) observed in Korea. METHODS: The antimicrobial susceptibilities of 190 isolates of gonococci from Korea in 2000 were examined by NCCLS methods, and subsets of these isolates underwent mutation analysis of the quinolone resistance-determining regions (QRDRs) of gyrA and parC. Molecular epidemiological characterization of 25 Korean isolates and 54 isolates from overseas was performed by pulsed-field gel electrophoresis (PFGE) and the results compared. RESULTS: Most (172, 90.5%) of the 190 gonococci tested displayed reduced susceptibility to ciprofloxacin. All strains with high-level ciprofloxacin resistance (ciprofloxacin MIC >/= 4 mg/L) contained a double amino acid alteration at the 91 and 95 positions in the QRDR of GyrA and a single alteration in ParC. PFGE types of high-level QRNG in Korea were mostly different from those of other nearby countries. CONCLUSIONS: These results suggest that the observed increase in ciprofloxacin-resistant isolates is due to the mutation and spread of Korean multiclonal isolates rather than importation from overseas. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 451~455 | - |
dc.relation.isPartOf | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Substitution | - |
dc.subject.MESH | Anti-Infective Agents/pharmacology* | - |
dc.subject.MESH | Ciprofloxacin/pharmacology | - |
dc.subject.MESH | DNA Gyrase/genetics | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | DNA Topoisomerase IV/genetics | - |
dc.subject.MESH | Electrophoresis, Gel, Pulsed-Field | - |
dc.subject.MESH | Fluoroquinolones/pharmacology* | - |
dc.subject.MESH | Gonorrhea/epidemiology* | - |
dc.subject.MESH | Gonorrhea/microbiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Molecular Epidemiology | - |
dc.subject.MESH | Neisseria gonorrhoeae/drug effects* | - |
dc.subject.MESH | Neisseria gonorrhoeae/genetics* | - |
dc.title | Epidemiological characteristics and molecular basis of fluoroquinolone-resistant Neisseria gonorrhoeae strains isolated in Korea and nearby countries | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Tae Sook Kim | - |
dc.contributor.googleauthor | John W. Tapsall | - |
dc.contributor.googleauthor | Tiffany Shultz | - |
dc.contributor.googleauthor | Hee-Bok Oh | - |
dc.contributor.googleauthor | Yunsop Chong | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Jong Hwa Yum | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.identifier.doi | 10.1093/jac/dkh345 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J01237 | - |
dc.identifier.eissn | 1460-2091 | - |
dc.identifier.pmid | 15231766 | - |
dc.subject.keyword | N. gonorrhoeae | - |
dc.subject.keyword | pulsed-field gel electrophoresis | - |
dc.subject.keyword | ciprofloxacin | - |
dc.subject.keyword | resistance | - |
dc.subject.keyword | QRDRs | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 451 | - |
dc.citation.endPage | 455 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.54(2) : 451-455, 2004 | - |
dc.identifier.rimsid | 44497 | - |
dc.type.rims | ART | - |
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