211 526

Cited 2 times in

Fasting-induced Down-regulation of NADPH-diaphorase in the Magnocellular PVN of Rats

Authors
 Joo Young Lee  ;  Dong Won Kang  ;  Jeong Won Jahng  ;  Dong Goo Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.45(5) : 917-922, 2004 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2004
MeSH
Adrenalectomy ; Adrenomedullin ; Animals ; Dexamethasone/pharmacology ; Down-Regulation ; Fasting/metabolism* ; Male ; NADPH Dehydrogenase/analysis* ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase Type I ; Paraventricular Hypothalamic Nucleus/enzymology* ; Peptides/physiology ; Rats ; Rats, Sprague-Dawley ; Weight Gain
Keywords
Food deprivation ; hypothalamus ; neuronal nitric oxide synthase ; glucocorticoid
Abstract
In this study, we examined if glucocorticoids are required for the fasting-induced decrease of neuronal nitric oxide synthase (nNOS) in the magnocellular division of the paraventricular nucleus (PVN). Rats were adrenalectomized, subjected to 48 h of food deprivation with/without dexamethasone (5 mg/kg, 4 subcutaneous injections with 12 h intervals), and the brain slices were processed for NADPH-diaphorase (NADPH- d) staining, a histochemical marker for nNOS in neuronal cells. In food deprived adrenalectomized rats, but not in free fed intact rats, dexamethasone significantly decreased NADPH-d staining in the magnocellular PVN. We previously reported that food deprivation decreases nNOS in the magnocellular PVN of intact rats. Thus, the present results together with our previous report suggest that although glucocorticoids are required for fasting-induced nNOS down-regulation in the magnocellular PVN, glucocorticoids may not be directly involved and some other molecular signals produced by food deprivation may play a pivotal role over glucocorticoid in the regulatory pathway for nNOS expression in this brain region.
Files in This Item:
T200401710.pdf Download
DOI
10.3349/ymj.2004.45.5.917
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112772
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links