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허혈성심질환 발생예측모형(health risk appraisal) 개발 연구

Other Titles
 Development of the Individualized Health Risk Appraisal Model of Ischemic Heart Disease Risk in Korea 
Authors
 지선하  ;  송지원  ;  김정희  ;  장양수  ;  김상연  ;  조홍근 
Citation
 한국지질동맥경화학회지, Vol.14(2) : 153-168, 2004 
Journal Title
 한국지질동맥경화학회지 
ISSN
 1226-4393 
Issue Date
2004
Keywords
Ischemic heart disease ; Individual health risk ; Korean
Abstract
Objectives: The objectives of this study were to develop a health risk appraisal (HRA) model of ischemic heart disease (IHD) and to evaluate the model’s ability to accurately predict individual IHD risk. Methods: The sample data were from a prospective cohort study in Korea with a follow-up period of 10 years. Between 1993 and 2002 (8,635,809 person-year), there were 10,528 incident cases of IHD (121.9/100,000 person- years). First, we developed the HRA based on the multivariate Cox proportional hazards model using a prospective cohort data with split-half data (50% random sample). Second, we compared the probability of IHD predicted by the model to the actual number of cases observed in the other 50% of the random sample of the study population. Results: The HRA model of IHD developed in the study includes age, total cholesterol, systolic blood pressure, smoking, and diabetes mellitus for men and women. Multivariate Cox proportional hazards models were used to test the HRA model validation. Compared with men and women in the lower 10 percentile of predicted risk, those in the upper 10 percentile had an increased actual risk of IHD. The area-under-the-curve in ROC was 0.75 to 0.80. Conclusion: The models performance was satisfactory for estimating IHD risk for individual men and women aged 30∼79 years
Files in This Item:
T200401563.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112686
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