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항원 85 복합체를 과발현하는 재조합 BCG의 개발 및 마우스 모델에 있어서의 결핵균 감염에 대한 방어 효능
DC Field | Value | Language |
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dc.contributor.author | 전보영 | - |
dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-07-14T17:19:15Z | - |
dc.date.available | 2015-07-14T17:19:15Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112646 | - |
dc.description.abstract | Tuberculosis (TB) remains an enormous global health problem, and a new vaccine against TB more potent than the current inadequate BCG vaccine is urgently needed. We constructed three recombinant Mycobacterium bovis BCG (rBCG) strains over-expressing antigen (Ag) 85A, Ag85B, or both of M. tuberculosis using their own promoter and secretory sequence, or hsp60 promoter. SDS-PAGE analysis of rBCG proteins showed overexpression of Ag85A and Ag85B proteins in higher level than of those in their parental strain of BCG. In addition, rBCG(rBCG/B.FA) over-expressing Ag85A and Ag85B induced strong IFN-γ production in splenocytes. However, there was no significant difference in protective efficacy between rBCG and their parental BCG strain. In this study, therefore, rBCG over-expressing Ag85A, Ag85B, or both failed to show enhanced protection against M. tuberculosis infection in a mouse model. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 125~131 | - |
dc.relation.isPartOf | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 항원 85 복합체를 과발현하는 재조합 BCG의 개발 및 마우스 모델에 있어서의 결핵균 감염에 대한 방어 효능 | - |
dc.title.alternative | Construction of Recombinant BCGs Overexpressing Antigen 85 Complex and Their Protective Efficacy against Mycobacterium tuberculosis Infection in a Mouse Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | 이승헌 | - |
dc.contributor.googleauthor | 전보영 | - |
dc.contributor.googleauthor | 배길한 | - |
dc.contributor.googleauthor | 김효준 | - |
dc.contributor.googleauthor | 조상래 | - |
dc.contributor.googleauthor | 이혜영 | - |
dc.contributor.googleauthor | 박영길 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02761 | - |
dc.identifier.eissn | 2005-6184 | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Vaccine | - |
dc.subject.keyword | Recombinant BCG | - |
dc.contributor.alternativeName | Jeon, Bo Young | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 57 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 125 | - |
dc.citation.endPage | 131 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.57(2) : 125-131, 2004 | - |
dc.identifier.rimsid | 57799 | - |
dc.type.rims | ART | - |
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