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Ultrastructural observation of human neutrophils during apoptotic cell death triggered by Entamoeba histolytica.

Authors
 Seobo Sim  ;  Kyeong Ah Kim  ;  Myeong Heon Shin  ;  Kyung-il Im  ;  Soon-Jung Park  ;  Tai-Soon Yong 
Citation
 KOREAN JOURNAL OF PARASITOLOGY, Vol.42(4) : 205-208, 2004 
Journal Title
 KOREAN JOURNAL OF PARASITOLOGY 
ISSN
 0023-4001 
Issue Date
2004
MeSH
Animals ; Apoptosis/physiology* ; Entamoeba histolytica/physiology* ; Host-Parasite Interactions/physiology ; Humans ; In Vitro Techniques ; Neutrophils/physiology ; Neutrophils/ultrastructure*
Keywords
Entamoeba histolytica ; neutrophils ; transmission electron microscopy ; apoptosis ; inflammation
Abstract
Neutrophils are important effector cells against protozoan extracellular parasite Entamoeba histolytica, which causes amoebic colitis and liver abscess in human beings. Apoptotic cell death of neutrophils is an important event in the resolution of inflammation and parasite's survival in vivo. This study was undertaken to investigate the ultrastructural aspects of apoptotic cells during neutrophil death triggered by Entamoeba histolytica. Isolated human neutrophils from the peripheral blood were incubated with or without live trophozoites of E. histolytica and examined by transmission electron microscopy (TEM). Neutrophils incubated with E. histolytica were observed to show apoptotic characteristics, such as compaction of the nuclear chromatin and swelling of the nuclear envelop. In contrast, neutrophils incubated in the absence of the amoeba had many protrusions of irregular cell surfaces and heterogenous nuclear chromatin. Therefore, it is suggested that Entamoeba-induced neutrophil apoptosis contribute to prevent unwanted tissue inflammation and damage in the amoeba-invaded lesions in vivo.
Files in This Item:
T200401437.pdf Download
DOI
10.3347/kjp.2004.42.4.205
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Soon Jung(박순정) ORCID logo https://orcid.org/0000-0002-0423-1944
Shin, Myeong Heon(신명헌) ORCID logo https://orcid.org/0000-0001-8207-6110
Sim, Seo Bo(심서보)
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
Im, Kyung Il(임경일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112578
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