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The Diagnostic Value of the Adenosine Deaminase Activity in the Pleural Fluid of Renal Transplant Patients with Tuberculous Pleural Effusion

Authors
 Jae Ho Chung  ;  Yu Seun Kim  ;  Sung Kyu Kim  ;  Joon Chang  ;  Se Kyu Kim  ;  Young Sam Kim  ;  Moo Suk Park  ;  Kiil Park  ;  Soon Il Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.45(4) : 661-664, 2004 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2004
MeSH
Adenosine Deaminase/metabolism* ; Adult ; Female ; Humans ; Immunocompromised Host ; Kidney Transplantation* ; Male ; Pleural Effusion/diagnosis* ; Pleural Effusion/enzymology* ; Pleural Effusion/microbiology ; Tuberculosis, Pleural/diagnosis* ; Tuberculosis, Pleural/immunology ; Tuberculosis, Pleural/metabolism
Keywords
Pleural effusion ; tuberculosis ; adenosine deaminase ; kidney transplant ; immunocompromised host
Abstract
The assessment of the adenosine deaminase activity (ADA) in the pleural effusion is used for the diagnosis of tuberculous pleural effusion (TPE). To examine whether the procedure can be applied to immunocompromised patients, we analyzed the ADA activity in the pleural fluid of renal transplant recipients. We studied 23 renal transplant patients with TPE (21 men and 2 women; the mean age, 33 years). They were treated at the Yonsei University Hospital between January 1985 and December 2001. Patients with granuloma in the pleural biopsy specimen or positive for Mycobacterium tuberculosis in the pleural fluid culture were recruited. The ADA activity in the pleural effusion of 23 renal transplant patients with TPE was compared with 23 immunocompetent patients with TPE. The mean ADA activity was 69.5 ± 4.6 in renal transplant patients and 65.0 ± 4.9 U/L in immunocompetent patients. Applying the 40 U/L cut-off point, the positivity of ADA was 91.3% in renal transplant patients, and 86.9% in immunocompetent patients. We thus concluded that the measurement of ADA in the pleural fluid is a useful means in the diagnosis of TPE in renal transplant patients.
Files in This Item:
T200401379.pdf Download
DOI
10.3349/ymj.2004.45.4.661
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Paik, Yong Han(백용한)
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Dong Ki(이동기) ORCID logo https://orcid.org/0000-0002-0048-9112
Lee, Sang In(이상인)
Lee, Se Joon(이세준) ORCID logo https://orcid.org/0000-0002-2695-2670
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112563
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