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Quetiapine의 정신분열증에 대한 효능 및 안전성에 관한 개방 연구

Other Titles
 Open clinical trial to assess the efficacyand safety of quetiapine in patients of schizophrenia 
Authors
 이홍식  ;  강대엽  ;  안석균  ;  김유석  ;  김세주  ;  전덕인  ;  김영신  ;  송동호 
Citation
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.15(1) : 51-57, 2004 
Journal Title
Korean Journal of Psychopharmacology(대한정신약물학회지)
ISSN
 1017-5717 
Issue Date
2004
Keywords
Quetiapine ; Extrapyramidal symptoms ; Efficacy ; Safety
Abstract
Objective : The efficacy, tolerability and safety of quetiapine in schizophrenia patients diagnosed by the diagnostic criteria of schizophrenia of the Diagnostic Statistical Manual 4th edition was studied in psychiatric department of 4 hospital in Korea. Methods : Sixty-four patients (male 31, female 33 : age 34.2±10.4 years: illness duration 8.1±8.3 years) who showed acute exacerbation. pm1ial response, or intolerable adverse event to previous antipsychotic drugs were recruited. Doses of quetiapine were adjusted to maximize efficacy and minimize adverse events. Efficacy was assessed by the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI) scale. Tolerability and safety were assessed by reports of adverse events. clinically significant abnonnal laboratory values and changes from the baseline to week 8 in the Abnonnallnvoluntary Movement Scale (AIMS) and Simpson-Angus total score as index of extrapyramidal symptoms (EPS). Results : Fiftythree patients completed the 8 weeks trial. The clinical symptoms indexed by BPRS were significantly improved (baseline score=37.9±13.0. score at the end=24.3±13.6 : F=41.5. d.f.=2.4. p=0.000). The CGI score of severity of illness was also significantly reduced (baseline score=4.7±1.1. score at the end= 3.6±1.2 : F=27.6, d.f.=2.2, p=0.000. The frequencies of the worsening of AIMS and Simpson-Angus scores at the end of study were 7.5% and 4.2%, respectively. The most common adverse events of at least moderate intensity were EPS (9.3%). Constipation (6.3%). and sedation (4.7%). Conclusion : The results of this study suggest that quetiapine is effective, may have a favorable EPS, and has overall safe tolerability in the patients with schizophrenia, and schizophreniform disorder.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, You Seok(김유석)
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112537
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