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Doxylamine 중독에서 CK (creatine kinase) 최고치가 높은 경우를 예측할 수 있는 인자

Other Titles
 Predictors of High Peak Serum CK Levels in Doxylamine Intoxication 
Authors
 신혜정  ;  이성경  ;  윤방부  ;  강희철  ;  강용준  ;  조경희  ;  김경곤 
Citation
 Journal of the Korean Academy of Family Medicine (가정의학회지), Vol.25(3) : 216-223, 2004 
Journal Title
 Journal of the Korean Academy of Family Medicine (가정의학회지) 
ISSN
 2005-6443 
Issue Date
2004
Keywords
doxylamine ; CK
Abstract
Background : Because doxylamine succinate (DS) is an over-the-counter medicine, it can be obtained easily and is frequently used in suicidal attempts. Patients usually recover without serious complications, but occasionally rhabdomyolysis and even death can occur in DS intoxication. In this study, the authors tried to find out the independent predictors of high peak serum CK levels, i.e. probable rhabdomyolysis in DS intoxication. Methods : The medical records of 41 patients who visited a hospital for DS intoxication from January 1, 2002 to April 30, 2003, were reviewed retrospectively. Results : In the group of DS only, initial occult blood of urine (P=0.003), initial WBC count (P=0.003) and confusion (P= 0.007) were the best predictors of the peak serum CK level (r2=0.724). In the group of DS with other drugs intoxication, initial creatinine level (P=0.003) and initial occult blood of urine (P=0.007) were the best predictors of the peak serum CK level (r2=0.784). In the cases of rhabdomyolysis patients, the time taken for the CK level to be increased over 1,000 IU/L was 1.9±0.6 days. Conclusion : In DS only intoxication, occult blood in initial urine analysis, initial high WBC count and confusion can be thought of as useful clinical predictors for high peak serum CK level case. In DS with other drugs intoxication, initial creatinine level and initial occult blood of urine can be considered as the best predictors. More than 2 days will be needed for the observation of serious complications in DS intoxication.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Cheol(강희철) ORCID logo https://orcid.org/0000-0002-0309-7448
Kim, Kyoung Kon(김경곤)
Youn, Bang Bu(윤방부)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112475
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