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Alendronate Sodium의 거식세포에서의 산화질소 유리 억제 효과

Other Titles
 The Suppressive Effect of Alendronate Sodium on Nitric Oxide Releaseby Macrophage 
 양익환  ;  이수현  ;  한창동 
 Journal of the Korean Orthopaedic Association (대한정형외과학회지), Vol.39(2) : 222-227, 2004 
Journal Title
 Journal of the Korean Orthopaedic Association (대한정형외과학회지) 
Issue Date
골용해 ; 산화질소 ; 거식세포 ; Alendronate sodium ; Osteolysis ; Nitric oxide ; Macrophage ; Alendronate Sodium
Purpose: This study was designed to present the effect of alendronate sodium on prevention of osteolysis after arthroplasty by suppression of macrophage. Materials and Methods: Submicron-sized titanium particles were made from TiAlV cylinder and plate after milling, and by repeated washing, centrifugation and floating method. 12 dogs were given alendronate by oral administration for 3 months and blood was sampled at 3 weeks, 6 weeks and 3 months. Monocytes were separated from canine blood by isopycnic centrifugation with Percoll solution and cultured in media with LPS, L-NMA, TiAlV particle (×1 SAR and ×5 SAR) for 24 hours. Nitric Oxide (NO) assay by Mendelow’s method and MTT assay as a cell viability test were performed. Results: Average diameter of TiAlV particles was 1.1±0.8 m (from 0.17 to 4.0 m). Particles less than 1.0 m were 55% and 3.0 m, 96%. Compared with control group, there was slight decrease of NO production in 3 weeks group with no statistic difference, but there was significant decrease in 6 weeks and 3 months group statistically. Conclusion: Administration of alendronate for more than 6 weeks may be effective in suppression of macrophage, prevention of osteolysis after arthroplasty.
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1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Yang, Ick Hwan(양익환)
Lee, Soo Hyun(이수현)
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