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Alendronate Sodium의 거식세포에서의 산화질소 유리 억제 효과
DC Field | Value | Language |
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dc.contributor.author | 양익환 | - |
dc.contributor.author | 이수현 | - |
dc.date.accessioned | 2015-07-14T17:13:06Z | - |
dc.date.available | 2015-07-14T17:13:06Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1226-2102 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112441 | - |
dc.description.abstract | Purpose: This study was designed to present the effect of alendronate sodium on prevention of osteolysis after arthroplasty by suppression of macrophage. Materials and Methods: Submicron-sized titanium particles were made from TiAlV cylinder and plate after milling, and by repeated washing, centrifugation and floating method. 12 dogs were given alendronate by oral administration for 3 months and blood was sampled at 3 weeks, 6 weeks and 3 months. Monocytes were separated from canine blood by isopycnic centrifugation with Percoll solution and cultured in media with LPS, L-NMA, TiAlV particle (×1 SAR and ×5 SAR) for 24 hours. Nitric Oxide (NO) assay by Mendelow’s method and MTT assay as a cell viability test were performed. Results: Average diameter of TiAlV particles was 1.1±0.8 m (from 0.17 to 4.0 m). Particles less than 1.0 m were 55% and 3.0 m, 96%. Compared with control group, there was slight decrease of NO production in 3 weeks group with no statistic difference, but there was significant decrease in 6 weeks and 3 months group statistically. Conclusion: Administration of alendronate for more than 6 weeks may be effective in suppression of macrophage, prevention of osteolysis after arthroplasty. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 222~227 | - |
dc.relation.isPartOf | Journal of the Korean Orthopaedic Association (대한정형외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Alendronate Sodium의 거식세포에서의 산화질소 유리 억제 효과 | - |
dc.title.alternative | The Suppressive Effect of Alendronate Sodium on Nitric Oxide Releaseby Macrophage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학) | - |
dc.contributor.googleauthor | 양익환 | - |
dc.contributor.googleauthor | 이수현 | - |
dc.contributor.googleauthor | 한창동 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01839 | - |
dc.subject.keyword | 골용해 | - |
dc.subject.keyword | 산화질소 | - |
dc.subject.keyword | 거식세포 | - |
dc.subject.keyword | Alendronate sodium | - |
dc.subject.keyword | Osteolysis | - |
dc.subject.keyword | Nitric oxide | - |
dc.subject.keyword | Macrophage | - |
dc.subject.keyword | Alendronate Sodium | - |
dc.contributor.alternativeName | Yang, Ick Hwan | - |
dc.contributor.alternativeName | Lee, Soo Hyun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 222 | - |
dc.citation.endPage | 227 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Orthopaedic Association (대한정형외과학회지), Vol.39(2) : 222-227, 2004 | - |
dc.identifier.rimsid | 56174 | - |
dc.type.rims | ART | - |
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