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장기간의 여성호르몬치료가 혈소판 활성에 미치는 영향

Other Titles
 Effects of Long Term Hormone Therapy on Platelet Activation in Postmenopausal Women 
Authors
 임지애  ;  김상환  ;  이덕철 
Citation
 Journal of the Korean Academy of Family Medicine (가정의학회지), Vol.25(10) : 754-759, 2004 
Journal Title
Journal of the Korean Academy of Family Medicine(가정의학회지)
ISSN
 2005-6443 
Issue Date
2004
Keywords
hormone therapy ; estrogen ; platelet activation ; menopause
Abstract
Background : Platelet activation has been implicated in the pathogenesis of a number of diseases, which include atherosclerosis, coronary vascular disease, and cerebrovascular disease. There have been controversies with the influence of hormone therapy on platelet activation. The purpose of this study was to define the effect of long-term hormone therapy on platelet activation.

Methods : We recruited a total of 162 postmenopausal women aged 55 and above among wihch eighty healthy postmenopausal women had received hormone therapy for more than 5 years and the remaining eighty- two healthy postmenopausal women with no hormone therapyapy. Baseline characteristics as well as the parameters related to platelet activation were compared between the two groups using T-test. After platelet activation was defined by the reference range, multivariated logistic regression analysis was performed determining the odds ratio of hormone therapy on platelet activation.

Results : The MPC and PCDW were significantly lower in the HT group than the Non-HT group (P<0.001), which suggests that platelets were more activated in the HT group more than in the non-HT group. Multiple logistic regression analysis showed that the odds ratio of the possibility of platelet activation in HT group was 19 times (P<0.001).

Conclusion : Long term hormone therapy increased platelet activation significantly, which may be a contributing factor of thromboembolism.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Hwan(김상환)
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112236
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