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자발성 고혈압 쥐에서 만성 뇌 혈류 저하가 중대뇌동맥 폐색에 의한 세포 손상에 미치는 영향

Other Titles
 The Effect of Chronic Cerebral Hypoperfusion onMiddle Cerebral artery Occlusion-induced Cellular Damagein Spontaneous Hypertensive Rats 
 최선아  ;  김은희  ;  허지회  ;  이준홍  ;  김규식  ;  임성룡  ;  김경환 
 Korean Journal of Stroke (대한뇌졸중학회지), Vol.6(2) : 162-167, 2004 
Journal Title
 Korean Journal of Stroke (대한뇌졸중학회지) 
Issue Date
Middle cerebral artery occlusion ; Chronic hypoperfusion
Background: An ischemic stroke can result from various mechanisms such as atherothrombosis, cardioem-bolism or hemodynamic compromise. It has been reported that patients with atherothrombotic stroke have lesssevere neurological deficits and smaller cerebral infarctions than those with cardioembolic strokes. When exposedto a sufficient but sublethal alteration of their environment, most living organisms acquire transient tolerance tosubsequent and other lethal environmental changes. Methods: We examined the effect of chronic cerebral hypop-erfusion on middel cerebral artery occlusion/reperfusion (MCAO/R)-induced cellular damage. Spontaneoushypertensive rats (SHR) that were bred for 4 weeks after bilateral common carotid artery ligation (BCAL) or shamoperation were subjected to MCAO/R using a nylon suture model. In paraffin sections obtained from aubjects ineach group, in situnick translation study were performed and number of dUTP incorporated cells were counted. Results: The number of positive cells in the in situnick translation study, which was taken as an indication of cel-lular injury, was significantly reduced in the chronic cerebral hypoperfusion group (166.33±349.93) when com-pared with those in the sham operation group (1132.08±1363.64) (p<0.05). Conclusions: The findings of thisstudy provide experimental evidence for the hypothesis that chronic sublethal cerebral hypoperfusion is protectivefor subsequent severe ischemic insults.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gyung Whan(김경환) ORCID logo https://orcid.org/0000-0001-7053-4372
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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