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자발성 고혈압 쥐에서 만성 뇌 혈류 저하가 중대뇌동맥 폐색에 의한 세포 손상에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2015-07-14T17:06:42Z | - |
dc.date.available | 2015-07-14T17:06:42Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1229-4101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112229 | - |
dc.description.abstract | Background: An ischemic stroke can result from various mechanisms such as atherothrombosis, cardioem-bolism or hemodynamic compromise. It has been reported that patients with atherothrombotic stroke have lesssevere neurological deficits and smaller cerebral infarctions than those with cardioembolic strokes. When exposedto a sufficient but sublethal alteration of their environment, most living organisms acquire transient tolerance tosubsequent and other lethal environmental changes. Methods: We examined the effect of chronic cerebral hypop-erfusion on middel cerebral artery occlusion/reperfusion (MCAO/R)-induced cellular damage. Spontaneoushypertensive rats (SHR) that were bred for 4 weeks after bilateral common carotid artery ligation (BCAL) or shamoperation were subjected to MCAO/R using a nylon suture model. In paraffin sections obtained from aubjects ineach group, in situnick translation study were performed and number of dUTP incorporated cells were counted. Results: The number of positive cells in the in situnick translation study, which was taken as an indication of cel-lular injury, was significantly reduced in the chronic cerebral hypoperfusion group (166.33±349.93) when com-pared with those in the sham operation group (1132.08±1363.64) (p<0.05). Conclusions: The findings of thisstudy provide experimental evidence for the hypothesis that chronic sublethal cerebral hypoperfusion is protectivefor subsequent severe ischemic insults. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 162~167 | - |
dc.relation.isPartOf | Korean Journal of Stroke (대한뇌졸중학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 자발성 고혈압 쥐에서 만성 뇌 혈류 저하가 중대뇌동맥 폐색에 의한 세포 손상에 미치는 영향 | - |
dc.title.alternative | The Effect of Chronic Cerebral Hypoperfusion onMiddle Cerebral artery Occlusion-induced Cellular Damagein Spontaneous Hypertensive Rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | 최선아 | - |
dc.contributor.googleauthor | 김은희 | - |
dc.contributor.googleauthor | 허지회 | - |
dc.contributor.googleauthor | 이준홍 | - |
dc.contributor.googleauthor | 김규식 | - |
dc.contributor.googleauthor | 임성룡 | - |
dc.contributor.googleauthor | 김경환 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02121 | - |
dc.subject.keyword | Middle cerebral artery occlusion | - |
dc.subject.keyword | Chronic hypoperfusion | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 6 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 162 | - |
dc.citation.endPage | 167 | - |
dc.identifier.bibliographicCitation | Korean Journal of Stroke (대한뇌졸중학회지), Vol.6(2) : 162-167, 2004 | - |
dc.identifier.rimsid | 37985 | - |
dc.type.rims | ART | - |
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