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자가통증조절시 병용한 ondansetron과 naloxone이 술 후 진통 효과 및 부작용에 미치는 영향

Other Titles
 Effects of Ondansetron or Naloxone Patient-Controlled Analgesia on Postoperative Analgesia and Side Effects 
 한동우  ;  장철호  ;  이윤우  ;  노정섭  ;  심규대  ;  이종석 
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.46(4) : 434-438, 2004 
Journal Title
Issue Date
fentanyl ; naloxone ; ondansetron ; patient-controlled analgesia
BACKGROUND: Opioid delivered by PCA (patient-controlled analgesia) is effective at relieving pain after surgery, but it is associated with side effects, such as nausea, vomiting, pruritus, respiratory depression, and urinary retention. The purpose of this study was to compare fentanyl-related side effects and the quality of analgesia when naloxone or ondansetron was added to IV PCA regimen.

METHODS: Ninety patients undergoing lumbar laminectomy were enrolled in this study. General anesthesia was maintained with 50% N2O and enflurane. In the recovery room patients received a 1 µg/kg bolus of fentanyl, and addition normal saline 2 ml (group C), ondansetron 4 mg (group O), or naloxone 0.04 mg (group N). Simultaneously intravenous fentanyl PCA with normal saline (group C), ondansetron 4 mg (group O), or naloxone 0.36 mg (group N) was commenced. Pain scores and side effects were assessed on postoperative days (PODs) 0, 1, and 2 using a VAS (visual analogue scale).

RESULTS: The incidences of vomiting in the groups C, O, and N were 13.2%, 13.2%, and 3.3%, respectively. The VAS scores for nausea on PODs 0 and 1 in group N were significantly lower than in group C. The VAS scores for sedation on POD 0 in group N was lower than in group C, and on POD 2 lower than in group O. No differences in the VAS for pain and urinary retention were observed between the three groups.

CONCLUSIONS: Low-dose naloxone with IV fentanyl PCA is effective at reducing opioid-related nausea and sedation without attenuating the quality of analgesia.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Kyu Dae(심규대)
Lee, Youn Woo(이윤우)
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
Chang, Chul Ho(장철호) ORCID logo https://orcid.org/0000-0001-5647-8298
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
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