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익상편 절제술 후 괴사성 공막염이 발생한 환자의 눈물에서 TNF-alpha 와 MMP-9 의 증가

Other Titles
 Increased Tear TNF-alpha and MMP-9 in Patients with Necrotizing Scleritis after Pterygium Excision 
Authors
 신정철  ;  임찬영  ;  서경률  ;  이준행 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.45(5) : 720-724, 2004 
Journal Title
 Journal of the Korean Ophthalmological Society  (대한안과학회지) 
ISSN
 0378-6471 
Issue Date
2004
Abstract
Purpose: We collected tear or scleral tissues of necrotizing scleritis after pterygium excision, and evaluated them for tumor necrosis factor (TNF)-alpha and matrix metalloproteinase (MMP)-9 to elucidate the molecular basis and seek for treatment of this disease. Methods: Three patients with necrotizing scleritis after pterygium excision were evaluated for MMP-9 and TNF-alpha in tear and scleral tissue by Western blot analysis. Results: Before treatment with corticosteroid, the patients´ tear samples showed increased expression of TNF-alpha and MMP-9 compared to those of the contralateral eye. After treatment, the expression of TNF-alpha and MMP-9 was decreased compared to those of the pre-treated tear samples. The patients´ sclera showed increased expression of MMP-9 compared to that of the donors sclera and the patients conjunctiva. Conclusions: Our results: suggest that cytokine-related inflammation plays role in the pathophysiology of necrotizing scleritis and strongly supports, under the guarantee of negative microbiological culture, the prompt use of corticosteroid and immunosuppressive agents to help suppress the progression of this disease.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Lee, Joon Haeng(이준행)
Im, Chan Young(임찬영)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112193
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