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비만 여성에서 Sibutramine이 혈중 Adipocytokine에 미치는 영향

Other Titles
 The Effect of Sibutramine on the Serum Adiponectin Level in Obese Women 
 윤수지  ;  김철식  ;  허갑범  ;  김경래  ;  이현철  ;  임승길  ;  차봉수  ;  안철우  ;  김경욱  ;  김똘미  ;  남주영  ;  박종숙 
 Journal of Korean Society for the Study of Obesity (대한비만학회지), Vol.13(1) : 22-33, 2004 
Journal Title
 Journal of Korean Society for the Study of Obesity  (대한비만학회지) 
Issue Date
Backgraund: The aim of this study was to evaluate the effects of sibutramine on serum adiponenctin levels, body mass index, body composition and insulin resistance in obesity women. Methods: Twenty-eight healthy, non-diabetic, obese (BMI >25 kg/m²) women (mean age: 34.46±13.67 years, BMI: 31.00±4.10 kg/m²) were enrolled in this study, and designed as sibutramine 10 mg, administered orally, once daily for 12 weeks period. We assessed body composition, and measured the level of serum adiponectin, TNF-α, insulin, C-peptide and various biochemical parameters. Results: Twelve weeks of 10 mg/day sibutramine treatment achieved significant decrease in BMI from 31.00±4.10 to 28.72±4.16 kg/m² (P<0.01), total fat mass from 30.61±5.86 to 26.39±6.10 kg (P<0.01), percent body fat mass from 37.75±3.75 to 34.99±4.30% (P<0.01). Abdominal subcutaneous and visceral adipose tissue area were reduced from 315.74±125.35 to 263.71± 117.87 cm² and from 114.77±41.14 to 91.88±33.05 cm² (P<0.01). Cross-sectional area of low density muscle (LDM) at the mid thigh decreased from 17.22±7.45 to 11.58±5.90 cm² (P<0.01). Insulin resistance (IR, as measured using the homeostasis model assessment of insulin resistance) decreased from 2.76±1.37 to 2.20±1.12 (P<0.05). Serum adiponectin levels were increased from 5.34±1.27 to 6.37±1.67 μg/mL (P<0.01). Serum TNF-α levels were not statistically significant decreased (12.25±2.75 to 11.47±2.39 pg/mL). Conclusion: In this study, the change of HOMAIR, adiponectin, free fatty acids, triglyceride and mid thigh low density muscle preceded weight loss. Therefore, the change of insulin resistance, fatty acids metabolism and energy homeostasis preceded weight loss. It is highly likely that this is in part caused by altered fatty acid metabolism, β3-adrenoreceptors, or uncoupling protein. which is led by the increase in plasma adiponectin level.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김경래(Kim, Kyung Rae)
김경욱(Kim, Kyung Wook)
김똘미(Kim, Dol Mi)
김철식(Kim, Chul Sik)
남주영(Nam, Ju Young)
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
안철우(Ahn, Chul Woo)
이현철(Lee, Hyun Chul)
임승길(Lim, Sung Kil)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
허갑범(Huh, Kap Bum)
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