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베체트병(Behcet's disease) 환자에서 항핵항체(Antinuclear antibody)의 발현에 관한 연구

Other Titles
 Antinuclear antibodies in Patient with Behcet's Disease 
 천은영  ;  박상건  ;  이성낙  ;  이은소  ;  방동식  ;  이광훈  ;  이주희  ;  조영훈 
 Korean Journal of Dermatology (대한피부과학회지), Vol.42(5) : 545-550, 2004 
Journal Title
Korean Journal of Dermatology(대한피부과학회지)
Issue Date
Behcets disease ; Antinuclear antibody
Background: Behtiet´s disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear.
Objective: This study was to investigate the association of antinuclear antibodies (ANA) with Behcet´s disease.
Methods: The patients in this study were diagnosed at Severance Hospital Behcet´s Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Behcet´s disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA.
1. Of the 554 cases of Behtcet´s disease, 46 cases (8.3%) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8%) were ANA positive. (p=0.0003)
2. In ANA titers 38 cases (82.6%) showed low titer (1:40+, 1:160-), 5 cases (10.9%) intermediate titer (1:160+, 1:640-), and 3 cases high titer (>1:640+). There was no significant difference in intermediate and high titers between complete (17.9%) and incomplete type (14.3%).
3. In immunofluorescence patterns of ANA, 17 cases (37%) were speckled pattern, 5 cases (10.9%) homogeneous pattern, 3 cases (6.5%) centromere pattern. 2 cases (4.3%) nucleolar pattern and 19 cases (41.3%) unknown pattern.
4. Of 508 cases with negative ANA patients, 272 cases (53.5%) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4%) had minor symptoms (p=0.0027).
Conclusion: From this study ANA was more prevalent in Behcet´s disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Beh~et´s disease.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
Lee, Kwang Hoon(이광훈)
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Cho, Young Hun(조영훈)
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