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베체트병(Behcet's disease) 환자에서 항핵항체(Antinuclear antibody)의 발현에 관한 연구
DC Field | Value | Language |
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dc.contributor.author | 이주희 | - |
dc.contributor.author | 조영훈 | - |
dc.contributor.author | 방동식 | - |
dc.contributor.author | 이광훈 | - |
dc.date.accessioned | 2015-07-14T16:59:15Z | - |
dc.date.available | 2015-07-14T16:59:15Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111981 | - |
dc.description.abstract | Background: Behtiet´s disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear. Objective: This study was to investigate the association of antinuclear antibodies (ANA) with Behcet´s disease. Methods: The patients in this study were diagnosed at Severance Hospital Behcet´s Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Behcet´s disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA. Results: 1. Of the 554 cases of Behtcet´s disease, 46 cases (8.3%) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8%) were ANA positive. (p=0.0003) 2. In ANA titers 38 cases (82.6%) showed low titer (1:40+, 1:160-), 5 cases (10.9%) intermediate titer (1:160+, 1:640-), and 3 cases high titer (>1:640+). There was no significant difference in intermediate and high titers between complete (17.9%) and incomplete type (14.3%). 3. In immunofluorescence patterns of ANA, 17 cases (37%) were speckled pattern, 5 cases (10.9%) homogeneous pattern, 3 cases (6.5%) centromere pattern. 2 cases (4.3%) nucleolar pattern and 19 cases (41.3%) unknown pattern. 4. Of 508 cases with negative ANA patients, 272 cases (53.5%) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4%) had minor symptoms (p=0.0027). Conclusion: From this study ANA was more prevalent in Behcet´s disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Beh~et´s disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 545~550 | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 베체트병(Behcet's disease) 환자에서 항핵항체(Antinuclear antibody)의 발현에 관한 연구 | - |
dc.title.alternative | Antinuclear antibodies in Patient with Behcet's Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 천은영 | - |
dc.contributor.googleauthor | 박상건 | - |
dc.contributor.googleauthor | 이성낙 | - |
dc.contributor.googleauthor | 이은소 | - |
dc.contributor.googleauthor | 방동식 | - |
dc.contributor.googleauthor | 이광훈 | - |
dc.contributor.googleauthor | 이주희 | - |
dc.contributor.googleauthor | 조영훈 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02000 | - |
dc.subject.keyword | Behcets disease | - |
dc.subject.keyword | Antinuclear antibody | - |
dc.contributor.alternativeName | Lee, Ju Hee | - |
dc.contributor.alternativeName | Cho, Young Hun | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 545 | - |
dc.citation.endPage | 550 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.42(5) : 545-550, 2004 | - |
dc.identifier.rimsid | 53554 | - |
dc.type.rims | ART | - |
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