570 1812

Cited 0 times in

베체트병(Behcet's disease) 환자에서 항핵항체(Antinuclear antibody)의 발현에 관한 연구

DC Field Value Language
dc.contributor.author이주희-
dc.contributor.author조영훈-
dc.contributor.author방동식-
dc.contributor.author이광훈-
dc.date.accessioned2015-07-14T16:59:15Z-
dc.date.available2015-07-14T16:59:15Z-
dc.date.issued2004-
dc.identifier.issn0494-4739-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111981-
dc.description.abstractBackground: Behtiet´s disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear. Objective: This study was to investigate the association of antinuclear antibodies (ANA) with Behcet´s disease. Methods: The patients in this study were diagnosed at Severance Hospital Behcet´s Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Behcet´s disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA. Results: 1. Of the 554 cases of Behtcet´s disease, 46 cases (8.3%) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8%) were ANA positive. (p=0.0003) 2. In ANA titers 38 cases (82.6%) showed low titer (1:40+, 1:160-), 5 cases (10.9%) intermediate titer (1:160+, 1:640-), and 3 cases high titer (>1:640+). There was no significant difference in intermediate and high titers between complete (17.9%) and incomplete type (14.3%). 3. In immunofluorescence patterns of ANA, 17 cases (37%) were speckled pattern, 5 cases (10.9%) homogeneous pattern, 3 cases (6.5%) centromere pattern. 2 cases (4.3%) nucleolar pattern and 19 cases (41.3%) unknown pattern. 4. Of 508 cases with negative ANA patients, 272 cases (53.5%) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4%) had minor symptoms (p=0.0027). Conclusion: From this study ANA was more prevalent in Behcet´s disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Beh~et´s disease.-
dc.description.statementOfResponsibilityopen-
dc.format.extent545~550-
dc.relation.isPartOfKorean Journal of Dermatology (대한피부과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title베체트병(Behcet's disease) 환자에서 항핵항체(Antinuclear antibody)의 발현에 관한 연구-
dc.title.alternativeAntinuclear antibodies in Patient with Behcet's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthor천은영-
dc.contributor.googleauthor박상건-
dc.contributor.googleauthor이성낙-
dc.contributor.googleauthor이은소-
dc.contributor.googleauthor방동식-
dc.contributor.googleauthor이광훈-
dc.contributor.googleauthor이주희-
dc.contributor.googleauthor조영훈-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02000-
dc.subject.keywordBehcets disease-
dc.subject.keywordAntinuclear antibody-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.alternativeNameCho, Young Hun-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.alternativeNameLee, Kwang Hoon-
dc.rights.accessRightsfree-
dc.citation.volume42-
dc.citation.number5-
dc.citation.startPage545-
dc.citation.endPage550-
dc.identifier.bibliographicCitationKorean Journal of Dermatology (대한피부과학회지), Vol.42(5) : 545-550, 2004-
dc.identifier.rimsid53554-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.