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Effect of amniotic membrane after laser-assisted subepithelial keratectomy on epithelial healing : Clinical and refractive outcomes

Authors
 Hyung Keun Lee  ;  Jin Kook Kim  ;  Gong Je Seong  ;  In Sik Lee  ;  Kwang One Kim  ;  Eung Kweon Kim  ;  Sung Soo Kim 
Citation
 JOURNAL OF CATARACT AND REFRACTIVE SURGERY, Vol.30(2) : 334-340, 2004 
Journal Title
 JOURNAL OF CATARACT AND REFRACTIVE SURGERY 
ISSN
 0886-3350 
Issue Date
2004
MeSH
Adult ; Amnion/transplantation* ; Astigmatism/physiopathology ; Astigmatism/surgery* ; Biological Dressings ; Epithelial Cells/cytology ; Epithelium, Corneal/physiology* ; Female ; Humans ; Keratomileusis, Laser In Situ/methods* ; Male ; Myopia/physiopathology ; Myopia/surgery* ; Prospective Studies ; Refraction, Ocular/physiology ; Regeneration/physiology* ; Time Factors ; Treatment Outcome ; Visual Acuity/physiology ; Wound Healing/physiology*
Abstract
PURPOSE: To evaluate the effect of an amniotic membrane (AM) on reepithelialization time, corneal haze, and postoperative visual and refractive outcomes after laser-assisted subepithelial keratectomy (LASEK) for myopia and myopic astigmatism. SETTING: Department of Ophthalmology, Yonsei University College of Medicine, and Balgeunsesang Ophthalmology Clinic, Seoul, Korea. METHODS: One hundred fifty-two eyes of 84 patients with myopia or myopic astigmatism were prospectively evaluated for 6 months after LASEK. An AM was placed as a strip on the inferior limbus in 94 eyes of 54 patients after LASEK; 58 eyes of 30 patients served as the control group. Postoperative epithelial healing time, uncorrected visual acuity (UCVA), best corrected visual acuity, remaining refractive error, and corneal haze were examined. RESULTS: The reepithelialization time was shorter in the AM group (2.40 days +/- 0.94 [SD]) than in the control group (3.90 +/- 0.97 days) (P<.001). At 6 months, 86 eyes (91.5%) in the AM group had a UCVA of 20/25 or better and 90 eyes (95.7%) had a UCVA of 20/40 or better; 48 eyes (82.8%) and 53 eyes (91.4%) in the control group had a UCVA of 20/25 or better and 20/40 or better, respectively. The mean spherical equivalent in the AM group was -0.48 +/- 0.54 diopter (D) and in the control group, -0.94 +/- 0.60 D (P<.001). The corneal haze was significantly less in the AM group than in the control group (P<.001). CONCLUSION: Amniotic membrane use after LASEK induced rapid epithelial healing with more favorable visual and refractive outcomes and lower corneal haze scores than conventional LASEK.
Full Text
http://www.sciencedirect.com/science/article/pii/S0886335003005753
DOI
10.1016/S0886-3350(03)00575-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111669
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