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Effects of green tea polyphenol on preservation of human saphenous vein

DC FieldValueLanguage
dc.contributor.author박영환-
dc.contributor.author박종철-
dc.contributor.author서활-
dc.contributor.author한동욱-
dc.date.accessioned2015-07-14T16:48:38Z-
dc.date.available2015-07-14T16:48:38Z-
dc.date.issued2004-
dc.identifier.issn0168-1656-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111635-
dc.description.abstractThe potential role of green tea polyphenol (GtPP) in preserving the human saphenous vein was investigated under physiological conditions. The vein segments were incubated for 1, 3, 5, 7 and 14 days, either after 4h of treatment with 1.0mg/ml GtPP or in the presence of GtPP at the same concentration. After incubation, the endothelial cell viability, endothelial nitric oxide synthase (eNOS) expression and the vein histology were evaluated. When the veins were not treated with GtPP, the viability of the endothelial cells was significantly reduced with the progress in the culture time, and none of the cells expressed eNOS after 5 days. Furthermore, severe histological changes and structural damage were observed in the non-treated veins. In contrast, incubating the veins after 4h of GtPP treatment significantly prevented these phenomena. The cellular viability of the GtPP-treated vein was approximately 64% after 7 days, and eNOS expression was maintained up to 40%, compared to that of the fresh vein. The histological observations showed that the vasculature was quite similar to that of the fresh vein. When incubated with GtPP, the vein could also be preserved for 1 week under physiological conditions retaining both its cellular viability (61%) and eNOS expression level (45%) and maintaining its venous structure without any morphological changes. These results demonstrate that GtPP treatment may be a useful method for preserving the HSV.-
dc.description.statementOfResponsibilityopen-
dc.format.extent109~117-
dc.relation.isPartOfJournal of Biotechnology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of green tea polyphenol on preservation of human saphenous vein-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorDong-Wook Han-
dc.contributor.googleauthorYoung Hwan Park-
dc.contributor.googleauthorJong-Chul Park-
dc.contributor.googleauthorHwal Suh-
dc.contributor.googleauthorSuong-Hyu Hyon-
dc.contributor.googleauthorKwon-Yong Lee-
dc.contributor.googleauthorJeong Koo Kim-
dc.identifier.doi10.1016/j.jbiotec.2003.12.013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ01274-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0168165604000689-
dc.contributor.alternativeNamePark, Young Hwan-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameSuh, Hwal-
dc.contributor.alternativeNameHan, Dong Wook-
dc.rights.accessRightsnot free-
dc.citation.volume110-
dc.citation.number2-
dc.citation.startPage109-
dc.citation.endPage117-
dc.identifier.bibliographicCitationJournal of Biotechnology, Vol.110(2) : 109-117, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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