1 236

Cited 77 times in

Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis

DC FieldValueLanguage
dc.contributor.author김경환-
dc.contributor.author이민구-
dc.contributor.author조경희-
dc.date.accessioned2015-07-14T16:46:57Z-
dc.date.available2015-07-14T16:46:57Z-
dc.date.issued2004-
dc.identifier.issn0016-5085-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111578-
dc.description.abstractBACKGROUND & AIMS: Protease-activated receptor 2 can be stimulated by interstitially released trypsin during acute inflammation of the pancreas. In this study, we investigated the roles of pancreatic and circulatory protease-activated receptor 2 in the pathogenesis of acute pancreatitis by using in vitro and in vivo model systems. METHODS: Physiological and pathologic effects of protease-activated receptor 2 activation were measured in isolated pancreatic cells and in rats with experimental pancreatitis. Consequences of protease-activated receptor 2 activation on the systemic and inflammatory responses were measured after treatments with trypsin or protease-activated receptor 2-activating peptide. RESULTS: Stimulation of protease-activated receptor 2 in rat pancreatic acinar cells activated short-lasting (Ca(2+) signaling) and long-lasting (extracellular signal-related kinase) signaling pathways and protected the cells against bile-induced cell damage. More importantly, protease-activated receptor 2 activation ameliorated the pathologic effects observed in the in vivo model of cerulein-induced pancreatitis. Trypsin in the circulation of rats with taurocholate-induced severe acute pancreatitis reached levels sufficient to activate endothelial and immune cells to stimulate nitric oxide and interleukin-8 production, respectively. Most notably, activation of systemic protease-activated receptor 2 by circulating protease-activated receptor 2 agonists induced a hemodynamic response pattern similar to that observed in rats with severe acute pancreatitis. The effects of protease-activated receptor 2 agonists and acute pancreatitis were not additive. CONCLUSIONS: These findings suggest that protease-activated receptor 2 may have a dual role in acute pancreatitis: protecting acinar and duct cells against pancreatitis-induced cell damage while mediating or aggravating the systemic complications of acute pancreatitis, which are the major cause of mortality in the early phase of necrotizing pancreatitis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1844~1859-
dc.relation.isPartOfGASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHAnimals-
dc.subject.MESHBlood Pressure-
dc.subject.MESHCell Survival/physiology-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCeruletide-
dc.subject.MESHEndopeptidases/pharmacology-
dc.subject.MESHGene Expression-
dc.subject.MESHIn Vitro Techniques-
dc.subject.MESHMale-
dc.subject.MESHMonocytes/pathology-
dc.subject.MESHPancreas/cytology-
dc.subject.MESHPancreatic Ducts/cytology-
dc.subject.MESHPancreatitis/chemically induced-
dc.subject.MESHPancreatitis/metabolism*-
dc.subject.MESHPancreatitis/pathology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptor, PAR-2/genetics*-
dc.subject.MESHReceptor, PAR-2/metabolism*-
dc.subject.MESHTrypsin/blood-
dc.titleProtease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorWan Namkung-
dc.contributor.googleauthorWonsun Han-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorKyung Hee Cho-
dc.contributor.googleauthorShmuel Muallem-
dc.contributor.googleauthorXiang Luo-
dc.identifier.doi10.1053/j.gastro.2004.03.019-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ00917-
dc.identifier.eissn1528-0012-
dc.identifier.pmid15188179-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0016508504004494-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.alternativeNameCho, Kyung Hee-
dc.rights.accessRightsnot free-
dc.citation.volume126-
dc.citation.number7-
dc.citation.startPage1844-
dc.citation.endPage1859-
dc.identifier.bibliographicCitationGASTROENTEROLOGY, Vol.126(7) : 1844-1859, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.