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Nitric oxide is involved in lithium-induced immediate early gene expressions in the adrenal medulla

Authors
 Jeong Won Jahng  ;  Corinne M. Spencer  ;  Thomas A. Houpt  ;  Dong Goo Kim  ;  Si Ho Choi 
Citation
 EUROPEAN JOURNAL OF PHARMACOLOGY, Vol.489(1-2) : 111-116, 2004 
Journal Title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN
 0014-2999 
Issue Date
2004
MeSH
Adrenal Medulla/drug effects ; Adrenal Medulla/metabolism* ; Animals ; Cyclic AMP Response Element Modulator ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/pharmacology ; Gene Expression/drug effects* ; Genes, Immediate-Early/drug effects* ; Genes, fos/drug effects ; Image Processing, Computer-Assisted ; In Situ Hybridization ; Injections, Intraperitoneal ; Injections, Intraventricular ; Lithium/pharmacology* ; Male ; NG-Nitroarginine Methyl Ester/administration & dosage ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/physiology* ; Nitric Oxide Synthase/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Repressor Proteins*
Keywords
Lithium chloride ; NO (Nitric oxide) ; Stress axis ; c-Fos ; Inducible cAMP early repressor
Abstract
This study was conducted to determine if nitric oxide (NO) is involved in lithium-induced expression of c-Fos and inducible cAMP early repressor (ICER) in the adrenal gland. Rats received an intraperitoneal injection of isotonic lithium (76 mg/kg) with either an intracerebroventricle (i.c.v., 250 μg) or intraperitoneal (i.p., 30 mg/kg) Nω-nitro-l-arginine methyl ester (l-NAME) pretreatment. The adrenal expression of c-Fos and ICER was examined by in situ hybridization 1 h after the lithium injection. The cortical c-Fos/ICER expression induced by lithium was not modulated by l-NAME pretreatment. However, lithium-induced medullary expression of c-Fos was attenuated by central l-NAME, and ICER by systemic l-NAME. These results suggest that nitric oxide is, at least partly, involved in lithium-induced c-Fos/ICER expression in the adrenal medulla, and that central nitric oxide may play a different role from peripheral nitric oxide in lithium-induced activation of adrenal medulla.
Full Text
http://www.sciencedirect.com/science/article/pii/S0014299904001918
DOI
10.1016/j.ejphar.2004.02.035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111566
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