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Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene

Authors
 Kyung-Su Kim  ;  Joo-Heon Yoon  ;  Jong-Bum Yoo  ;  Joo-Hwan Lee  ;  Jeung Gweon Lee  ;  Ji-Hwan Ryu  ;  Won Jae Lee  ;  Thomas E. Eling  ;  Seung Joon Baek  ;  Jin Kook Kim 
Citation
 Biochemical and Biophysical Research Communications, Vol.325(4) : 1298-1303, 2004 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2004
MeSH
Anti-Inflammatory Agents, Non-Steroidal/pharmacology* ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects* ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclooxygenase Inhibitors/pharmacology* ; Cytokines/metabolism* ; Cytokines/pharmacology* ; Dose-Response Relationship, Drug ; Growth Differentiation Factor 15 ; Humans ; Mouth/drug effects ; Mouth/pathology ; Mouth Neoplasms/metabolism* ; Mouth Neoplasms/pathology* ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology
Keywords
Nonsteroidal anti-inflammatory drugs ; Oral cavity cancer ; Apoptosis ; NSAID-activated gene-1 ; Drosophila
Abstract
We have investigated whether NAG-1 is induced in oral cavity cancer cells by various NSAIDs and if apoptosis induced by NSAIDs can be linked directly with the induction of NAG-1. NAG-1 expression was increased by diclofenac, aceclofenac, indomethacin, ibuprofen, and sulindac sulfide, in the order of NAG-1 induction, but not by acetaminophen, piroxicam or NS-398. Diclofenac was the most effective NAG-1 inducer. Incubation with diclofenac inhibited cell proliferation and induced apoptosis. The expression of NAG-1 was observed in advance of the induction of apoptosis. Conditioned medium from NAG-1-overexpressing Drosophila cells inhibited SCC 1483 cells proliferation and induced apoptosis. In summary, some NSAIDs induce NAG-1 expression in oral cavity cancer cells and the induced NAG-1 protein appears to mediate apoptosis. Therefore, NSAIDs may be considered as a possible chemopreventive agent against oral cavity cancer.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X04025082
DOI
10.1016/j.bbrc.2004.10.176
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111553
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