Cited 79 times in
Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene
DC Field | Value | Language |
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dc.contributor.author | 김경수 | - |
dc.contributor.author | 윤주헌 | - |
dc.contributor.author | 이정권 | - |
dc.date.accessioned | 2015-07-14T16:46:12Z | - |
dc.date.available | 2015-07-14T16:46:12Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111553 | - |
dc.description.abstract | We have investigated whether NAG-1 is induced in oral cavity cancer cells by various NSAIDs and if apoptosis induced by NSAIDs can be linked directly with the induction of NAG-1. NAG-1 expression was increased by diclofenac, aceclofenac, indomethacin, ibuprofen, and sulindac sulfide, in the order of NAG-1 induction, but not by acetaminophen, piroxicam or NS-398. Diclofenac was the most effective NAG-1 inducer. Incubation with diclofenac inhibited cell proliferation and induced apoptosis. The expression of NAG-1 was observed in advance of the induction of apoptosis. Conditioned medium from NAG-1-overexpressing Drosophila cells inhibited SCC 1483 cells proliferation and induced apoptosis. In summary, some NSAIDs induce NAG-1 expression in oral cavity cancer cells and the induced NAG-1 protein appears to mediate apoptosis. Therefore, NSAIDs may be considered as a possible chemopreventive agent against oral cavity cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1298~1303 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/pharmacology* | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Cyclooxygenase Inhibitors/pharmacology* | - |
dc.subject.MESH | Cytokines/metabolism* | - |
dc.subject.MESH | Cytokines/pharmacology* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Growth Differentiation Factor 15 | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mouth/drug effects | - |
dc.subject.MESH | Mouth/pathology | - |
dc.subject.MESH | Mouth Neoplasms/metabolism* | - |
dc.subject.MESH | Mouth Neoplasms/pathology* | - |
dc.subject.MESH | Recombinant Proteins/metabolism | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.title | Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Kyung-Su Kim | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Jong-Bum Yoo | - |
dc.contributor.googleauthor | Joo-Hwan Lee | - |
dc.contributor.googleauthor | Jeung Gweon Lee | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Won Jae Lee | - |
dc.contributor.googleauthor | Thomas E. Eling | - |
dc.contributor.googleauthor | Seung Joon Baek | - |
dc.contributor.googleauthor | Jin Kook Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2004.10.176 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 15555568 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X04025082 | - |
dc.subject.keyword | Nonsteroidal anti-inflammatory drugs | - |
dc.subject.keyword | Oral cavity cancer | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | NSAID-activated gene-1 | - |
dc.subject.keyword | Drosophila | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.alternativeName | Lee, Jeung Gweon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 325 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1298 | - |
dc.citation.endPage | 1303 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.325(4) : 1298-1303, 2004 | - |
dc.identifier.rimsid | 34915 | - |
dc.type.rims | ART | - |
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