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Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis

Authors
 Eun-Ryeong Hahm  ;  Yong Song Gho  ;  Chul-Hak Yang  ;  Kyu-Won Kim  ;  Chihoon Park  ;  Seyeon Park 
Citation
 Biochemical and Biophysical Research Communications, Vol.321(2) : 337-344, 2004 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2004
Keywords
AP-1 ; Curcumin analogs ; MMP-9 ; Angiogenesis
Abstract
In a previous study, we observed that some synthetic curcumin analogs inhibited complex formations between Fos–Jun heterodimer and activator protein-1 (AP-1) DNA. These curcumin analogs have been observed to repress the AP-1 transcription in AP-1-transfected cells and they also inhibited the increased expression of Jun/AP-1 protein by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the same cells. After the AP-1 inhibition by curcumin analogs in TPA-treated HT-1080 human fibrosarcoma cells, a decrease in mRNA expression of c-jun and MMP3 (stromelysin-1) has been observed. We also observed that curcumin analogs down-regulated the expression of MMP-9 (gelatinase-B), correlating with cellular invasion and migration in conditions such as tumor invasion and metastasis, through the electrophoretic mobility shift assay and gelatin zymography methods. Curcumin analogs showed an inhibitory effect on angiogenesis by various test methods including chicken chorioallantoic membrane assay, wound migration assay, invasion assay, and tube formation assay. Through the reverse transcriptase-polymerase chain reaction experiment, we confirmed that curcumin analogs down-regulated the expression of angiogenesis-associated genes, VEGF and MMP-9.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X04013981
DOI
10.1016/j.bbrc.2004.06.119
Appears in Collections:
5. Research Institutes (연구소) > Anesthesia and Pain Research Institute (마취통증의학연구소) > 1. Journal Papers
Yonsei Authors
Park, Se Yeon(박세연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111551
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