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Photodynamic Therapy with Verteporfin for Polypoidal Choroidal Vasculopathy of the Macula

 Lee S.C.  ;  Seong Y.S.  ;  Kwon O.W.  ;  Koh H.J.  ;  Kim S.S. 
 OPHTHALMOLOGICA, Vol.218(3) : 193-201, 2004 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Angiography ; Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/drug therapy* ; Choroidal Neovascularization/pathology ; Coloring Agents ; Female ; Fundus Oculi ; Humans ; Indocyanine Green ; Male ; Middle Aged ; Photochemotherapy*/adverse effects ; Photosensitizing Agents/adverse effects ; Photosensitizing Agents/therapeutic use* ; Porphyrins/adverse effects ; Porphyrins/therapeutic use* ; Retinal Hemorrhage/chemically induced ; Treatment Outcome ; Verteporfin ; Visual Acuity/drug effects
Choroidal neovascularization ; Photodynamic therapy ; Polypoidal choroidal vasculopathy ; Subretinal hemorrhage
PURPOSE: Indications for photodynamic therapy (PDT) have increased from age-related macular degeneration with choroidal neovascularization (CNV), containing more than 50% of the classic component, to occult CNV, myopic CNV and CNV due to ocular histoplasmosis syndrome. In the present study, the effect of PDT with verteporfin was examined in polypoidal choroidal vasculopathy (PCV) of the macula. METHODS: PDT was performed in 9 eyes with PCV of the macula. Fundus examination, fluorescein angiography, and indocyanine green angiography were performed before PDT and 3 months after PDT in all eyes. Optical coherence tomography was performed in 6 eyes. RESULTS: After the initial PDT, visual acuity was stabilized or improved in 8 eyes (89%), polypoid elements were obliterated in 7 eyes (78%), and vascular nets were reduced in 8 eyes (89%). Of 6 eyes that received optical coherence tomography, pigment epithelium detachment was reduced or disappeared in all eyes except 1, which developed a disciform scar. An additional PDT was performed in 4 eyes to decrease vascular leakage. During the follow-up period of 3-18 months, no reactivation of PCV was observed. CONCLUSION: PDT offers an effective way of treating PCV of the macula, by obliterating polypoid elements of the PCV. However, long-term follow-up is needed.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kwon, Oh Woong(권오웅)
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
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