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Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

Authors
 J. Y. Choi  ;  Y. Soo Park  ;  J. M. Kim  ;  K. Lee  ;  D. Yong  ;  Y. G. Song  ;  S. Y. Shin  ;  Y. Seon Park  ;  C. H. Cho 
Citation
 Clinical Microbiology and Infection, Vol.10(12) : 1098-1101, 2004 
Journal Title
 Clinical Microbiology and Infection 
ISSN
 1198-743X 
Issue Date
2004
Abstract
The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-beta-lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 x MIC and 1 x MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35 degrees C.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2004.00987.x/abstract
DOI
10.1111/j.1469-0691.2004.00987.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김준명(Kim, June Myung)
박윤수(Park, Yoon Soo)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
신소연(Shin, So Youn)
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
조정호(Cho, Cheong Ho)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111384
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