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Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

Authors
 J. Y. Choi  ;  Y. Soo Park  ;  J. M. Kim  ;  K. Lee  ;  D. Yong  ;  Y. G. Song  ;  S. Y. Shin  ;  Y. Seon Park  ;  C. H. Cho 
Citation
 Clinical Microbiology and Infection, Vol.10(12) : 1098-1101, 2004 
Journal Title
 Clinical Microbiology and Infection 
ISSN
 1198-743X 
Issue Date
2004
MeSH
Acinetobacter baumannii/drug effects* ; Anti-Bacterial Agents/pharmacology* ; Drug Synergism ; Imipenem/pharmacology* ; Microbial Sensitivity Tests ; Sulbactam/pharmacology* ; Time Factors ; beta-Lactamase Inhibitors*
Keywords
Acinetobacter baumannii ; imipenem ; sulbactam ; synergy
Abstract
The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-beta-lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 x MIC and 1 x MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35 degrees C.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2004.00987.x/abstract
DOI
10.1111/j.1469-0691.2004.00987.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Park, Yoon Soo(박윤수)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Shin, So Youn(신소연)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Cho, Cheong Ho(조정호)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111384
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