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Genetic characteristics and population study of 4 X-chromosomal STRs in Koreans: evidence for a null allele at DXS9898

Authors
 Hwan Young Lee  ;  Myung Jin Park  ;  Kyoung-Jin Shin  ;  Chong-Youl Kim  ;  Jong-Hoon Choi  ;  Ukhee Chung  ;  Ji-Eun Yoo  ;  Seon Yeong Lee  ;  Chan Kwon Jeong 
Citation
 INTERNATIONAL JOURNAL OF LEGAL MEDICINE, Vol.118(6) : 355-360, 2004 
Journal Title
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
ISSN
 0937-9827 
Issue Date
2004
MeSH
Chromosomes, Human, X/genetics* ; DNA Fingerprinting* ; Female ; Gene Frequency ; Humans ; Korea ; Linkage Disequilibrium ; Loss of Heterozygosity* ; Male ; Tandem Repeat Sequences/genetics*
Keywords
STR ; X-chromosome ; Null allele ; Korea
Abstract
The four X-chromosomal short tandem repeats (STRs), DXS9898, DXS6809, DXS7424 and DXS10011 were analyzed by single multiplex PCR in 150 male and 150 female Koreans. The loss of an allele at DXS9898 was observed in 13 out of 450 chromosomes (2.9%) and the PCR analysis showed that the X-chromosome with a null allele at DXS9898 has more than 1 kb deletion at the DXS9898 locus. Statistical analyses for these four X-STRs showed that they are highly informative for forensic application in Koreans. No linkage disequilibrium was observed among these four STRs and the previously reported five polymorphic STRs, HumARA, DXS101, GATA172D05, HPRTB and DXS8377 in Koreans. The test of homogeneity between allele frequencies revealed that there are some discrepancies in allele distributions between Koreans and Germans.
Full Text
http://link.springer.com/article/10.1007%2Fs00414-004-0456-1
DOI
10.1007/s00414-004-0456-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Park, Myung Jin(박명진)
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Lee, Hwan Young(이환영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111264
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