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Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease: metabolic changes that unravel novel drug targets

Authors
 Sang Sun Yoon  ;  Daniel J Hassett 
Citation
 EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, Vol.2(4) : 611-623, 2004 
Journal Title
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
ISSN
 1478-7210 
Issue Date
2004
MeSH
Animals ; Anti-Bacterial Agents/therapeutic use ; Biofilms ; Child ; ChronicDisease ; CysticFibrosis/complications* ; CysticFibrosis/drugtherapy ; CysticFibrosis/metabolism ; CysticFibrosis/pathology ; CysticFibrosis/physiopathology ; Humans ; Inflammation/pathology ; Mice ; Mucus/physiology ; PseudomonasInfections/complications* ; PseudomonasInfections/drugtherapy ; PseudomonasInfections/metabolism ; Pseudomonasaeruginosa/drugeffects ; Pseudomonasaeruginosa/genetics ; Pseudomonasaeruginosa/physiology
Keywords
alginate production ; anaerobic metabolism ; biofilms ; cystic fibrosis ; mucociliary clearance ; Pseudomonas aeruginosa ; quorum sensing
Abstract
The cystic fibrosis (CF) airways have an incompletely characterized defect in innate defense that eventually leads to bacterial infection and airway inflammation. Persistent Pseudomonas aerugionsa infection resulting from defective innate immunity and a bacterial phenotypic switch to a more intractable mucoid form inside the airway are now well established as important components of CF pathogenesis. Broad-based factors leading to chronic infection will be discussed with respect to: bacterial virulence in the context of biofilm formation, quorum sensing machinery and alginate overproduction, and failure of innate lung immunity in CF airways. In addition, a controversial question as to whether inflammation or infection comes first during CF airway disease will be addressed. Finally, a new hypothesis, that P. aeruginosa thrives as biofilms within the thickened anaerobic mucus layers, will be developed.
Full Text
http://informahealthcare.com/doi/abs/10.1586/14787210.2.4.611
DOI
10.1586/14787210.2.4.611
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111195
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