Adult ; Area Under Curve ; Asian Continental Ancestry Group* ; European Continental Ancestry Group* ; HIV Protease Inhibitors/administration & dosage ; HIV Protease Inhibitors/pharmacokinetics* ; Humans ; Indinavir/administration & dosage ; Indinavir/pharmacokinetics* ; Male
Abstract
We evaluated whether the pharmacokinetic parameters of indinavir differ in Koreans and Caucasians. Indinavir was administered orally to 8 healthy Koreans and 4 healthy Caucasians, and plasma indinavir levels were quantified by high performance liquid chromatography. No significant differences were observed in terms of its pharmacokinetic parameters; however, the AUC difference between the 2 groups may be significant for larger sample sizes.