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Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis.

Authors
 Jae-Seon So  ;  Choong-Gu Lee  ;  Ho-Keun Kwon  ;  Hwa-Jung Yi  ;  Chang-Suk Chae  ;  Jin-A Park  ;  Ki-Chul Hwang  ;  Sin-Hyeog Im 
Citation
 MOLECULAR IMMUNOLOGY, Vol.46(1) : 172-180, 2008 
Journal Title
MOLECULAR IMMUNOLOGY
ISSN
 0161-5890 
Issue Date
2008
MeSH
Administration, Oral ; Animals ; Arthritis, Experimental/immunology* ; Arthritis, Experimental/microbiology* ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; Cartilage/drug effects ; Cartilage/pathology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Collagen Type II/administration & dosage ; Collagen Type II/pharmacology ; Down-Regulation/drug effects ; Female ; Forkhead Transcription Factors/immunology ; Immune Tolerance/immunology* ; Immunoglobulin G/immunology ; Inflammation/immunology ; Lactobacillus casei/immunology* ; Probiotics* ; Rats ; Rats, Inbred Lew ; Th1 Cells/cytology ; Th1 Cells/drug effects ; Th1 Cells/immunology ; Up-Regulation/drug effects
Keywords
Rheumatoid arthritis ; Collagen-induced arthritis ; Lactobacillus casei ; Probiotics ; Oral tolerance ; Type II collagen ; Foxp3 ; Regulatory T cells
Abstract
probiotics in the induction of oral tolerance in autoimmune diseases. The main purpose of this study was to elucidate whether Lactobacillus casei (L. casei) affect the induction of oral tolerance in experimental rheumatoid arthritis (RA). Type II collagen (CII) alone or together with L. casei was orally administered into collagen-induced arthritis (CIA) rats, and its effects on the clinical and histopathological aspects of RA were investigated. Co-administration of L. casei with CII more effectively suppressed clinical symptoms, paw swelling, lymphocyte infiltration and destruction of cartilage tissues of experimental arthritis than the rats treated with CII alone. The enhanced therapeutic efficacy was associated with an increase in anti-inflammatory cytokines (IL-10 and TGF-beta) while decreasing pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, IL-12, IL-17, IFN-gamma and TNF-alpha). Co-administration of L. casei with CII more effectively suppressed CII-reactive T cell proliferation and the levels of Th1-type IgG isotypes (IgG2a and IgG2b), while up-regulating Foxp3 expression levels and the population of Foxp3(+) CD4(+) T cells. Our study provides evidence that L. casei could potentiate antigen-specific oral tolerance and suppress Th1-type immune responses of arthritic inflammation
Full Text
http://www.sciencedirect.com/science/article/pii/S0161589008005981
DOI
10.1016/j.molimm.2008.07.038
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111150
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