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Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis.

DC Field Value Language
dc.contributor.author황기철-
dc.date.accessioned2015-06-11T14:11:55Z-
dc.date.available2015-06-11T14:11:55Z-
dc.date.issued2008-
dc.identifier.issn0161-5890-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111150-
dc.description.abstractprobiotics in the induction of oral tolerance in autoimmune diseases. The main purpose of this study was to elucidate whether Lactobacillus casei (L. casei) affect the induction of oral tolerance in experimental rheumatoid arthritis (RA). Type II collagen (CII) alone or together with L. casei was orally administered into collagen-induced arthritis (CIA) rats, and its effects on the clinical and histopathological aspects of RA were investigated. Co-administration of L. casei with CII more effectively suppressed clinical symptoms, paw swelling, lymphocyte infiltration and destruction of cartilage tissues of experimental arthritis than the rats treated with CII alone. The enhanced therapeutic efficacy was associated with an increase in anti-inflammatory cytokines (IL-10 and TGF-beta) while decreasing pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, IL-12, IL-17, IFN-gamma and TNF-alpha). Co-administration of L. casei with CII more effectively suppressed CII-reactive T cell proliferation and the levels of Th1-type IgG isotypes (IgG2a and IgG2b), while up-regulating Foxp3 expression levels and the population of Foxp3(+) CD4(+) T cells. Our study provides evidence that L. casei could potentiate antigen-specific oral tolerance and suppress Th1-type immune responses of arthritic inflammation-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMOLECULAR IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAnimals-
dc.subject.MESHArthritis, Experimental/immunology*-
dc.subject.MESHArthritis, Experimental/microbiology*-
dc.subject.MESHCD4-Positive T-Lymphocytes/cytology-
dc.subject.MESHCD4-Positive T-Lymphocytes/drug effects-
dc.subject.MESHCD4-Positive T-Lymphocytes/immunology-
dc.subject.MESHCartilage/drug effects-
dc.subject.MESHCartilage/pathology-
dc.subject.MESHCell Movement/drug effects-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCollagen Type II/administration & dosage-
dc.subject.MESHCollagen Type II/pharmacology-
dc.subject.MESHDown-Regulation/drug effects-
dc.subject.MESHFemale-
dc.subject.MESHForkhead Transcription Factors/immunology-
dc.subject.MESHImmune Tolerance/immunology*-
dc.subject.MESHImmunoglobulin G/immunology-
dc.subject.MESHInflammation/immunology-
dc.subject.MESHLactobacillus casei/immunology*-
dc.subject.MESHProbiotics*-
dc.subject.MESHRats-
dc.subject.MESHRats, Inbred Lew-
dc.subject.MESHTh1 Cells/cytology-
dc.subject.MESHTh1 Cells/drug effects-
dc.subject.MESHTh1 Cells/immunology-
dc.subject.MESHUp-Regulation/drug effects-
dc.titleLactobacillus casei potentiates induction of oral tolerance in experimental arthritis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorJae-Seon So-
dc.contributor.googleauthorChoong-Gu Lee-
dc.contributor.googleauthorHo-Keun Kwon-
dc.contributor.googleauthorHwa-Jung Yi-
dc.contributor.googleauthorChang-Suk Chae-
dc.contributor.googleauthorJin-A Park-
dc.contributor.googleauthorKi-Chul Hwang-
dc.contributor.googleauthorSin-Hyeog Im-
dc.identifier.doi10.1016/j.molimm.2008.07.038-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04456-
dc.relation.journalcodeJ02259-
dc.identifier.eissn1872-9142-
dc.identifier.pmid18804867-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0161589008005981-
dc.subject.keywordRheumatoid arthritis-
dc.subject.keywordCollagen-induced arthritis-
dc.subject.keywordLactobacillus casei-
dc.subject.keywordProbiotics-
dc.subject.keywordOral tolerance-
dc.subject.keywordType II collagen-
dc.subject.keywordFoxp3-
dc.subject.keywordRegulatory T cells-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.rights.accessRightsnot free-
dc.citation.volume46-
dc.citation.number1-
dc.citation.startPage172-
dc.citation.endPage180-
dc.identifier.bibliographicCitationMOLECULAR IMMUNOLOGY, Vol.46(1) : 172-180, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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